Coronary Heart Disease And Coronary Heart Disease And Type 2 Diabetes Blood Lipids, Oxidative Stress And Inflammatory Cytokines In The Control Study

Objective: Explore lipid,oxidation and low-density lipoprotein (OX-LDL) and IL-6 in Coronary heart disease(CHD) combined type 2 diabetes mellitus (T2DM) patients occurrence and development of relations and their clinical significance.Methods:To use methed of delamination sample,cramp out 62 patients into two groups, 33 CHD patients are the first group,there are 20 men patients and 13 women patients in this group,the age is 40 to 79,average age is (62.67±10.48).29 coronary heart disease with diabetes mellitus patients is the second group, there are 18 men patients and 11 women patients in this group,the age is 42 to 76,average age is (60.08±9.66).Cholesterol (TC),triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were masured in patients with coronary artery disease(n=33), Coronary heart disease with diabetes mellitus(n=29)and normal controls(n=26). Using enzyme-linked immunosorbent (ELISA) for determining their study groups OX - LDL and IL - 6 levels of serum. Compare to Oxidative stress and inflammatory reaction, analysis of OX - LDL, IL - 6 and lipid correlation with their study groups.Results:Compare coronary heart disease combined type 2 diabetes group with simple CHD and normal control groups,OX-LDL level and IL-6 levels have significant differences(p<0.05). Compare simple CHD to normal control groups, OX-LDL level and IL-6 levels have significant differences(p<0.05).OX-LDL was not significantly associated with age(r=0.176,p=0.104), OX-LDL was positively correlated with total cholesterol (TC), triglycerides (TG) and low-density lipoprotein (LDL)( p<0.05). IL-6 was not significantly associated with age(r=0.091,p=0.401), IL-6 was positively correlated with total cholesterol (TC), triglycerides (TG) and low-density lipoprotein (LDL)( p<0.05).OX-LDL was positively correlated with IL-6(r=0.752,p<0.001).Conclusion: Oxidatie stress and inflammatory factor to clear exist in CHD patients,especially exist in coronary heart disease combined type 2 diabetes patients.lipoprotein was oxidize adorn,especially low-density lipoprotein has became oxidatie low-density lipoprotein.It is to advance artery gruel shape scleroses plaque.There are not many reports about lipids and oxidatie stress,so we splents a lot of times and funds to research toxicity of lipids and oxidatie stress.