Current Situation And Countermeasures On Rational Drug Use In Drug Interaction Studies

Now,multidrug combination administration of patients and sufferers was greatly promoted with the development of modem Medicine in the world.The conception of drug interactions is alteration of drug pharmacokinetics and/or pharmacokinetics caused by drug combination, dietary factor,Social habits and so on.The ideal condition of drug combination should be promoting drug potency,reducing dosage and adverse reaction,decreasing side reaction.In fact, adverse drug reaction rate was rising quickly along with increasing of multiple drug combination cases,drug interactions has being the important reason of drug adverse reaction and toxic reaction.From the condition of drug interactions data in our country,this problem didn't obtain relevant recognition.The quantity of research paper which have be enunciabled were minor, most of which were summary of traditional and western medicine compatibility experience or overview of clinical person in basement layer of municipalities rank or below,and most of which were presumptions and copies.The objective of this topic is to investigate and discuss the problem of drug interactions which was multiplicity,secluding and didn't obtain relevant recognition,to appeal citizen to think highly of safety problem induced by drug interactions,to approach and discover the existence of drug interactions and varietals regularity,and provide modified countermeasure,so as to preferable utilize the addition or synergistic reaction induced by drug interactions,reveal the adverse reaction possibly,avoid combination.The research and analytic result showed that,compared with developed countries,the cognition level of drug safety on account of drug interactions in our country had major distance, our research consciousness and level consciousness in this aspect were lower than developed countries such as USA,Sweden and so on.Now,the evaluate and control level to drug safety risk are raised constantly,but research of drug interactions was hysteretic relatively,to bring about challenge to our reasonable,safety and effective medication.To diminution this distance is our medical worker's duty-bound,relevant medicine branch and personnel at different levels should think much of this problem,carry out research of drug interactions as soon as possible, and give patient specific guidance,avoid drug induced sufferings occurring.This study provide ten strategies and suggestions about how to strengthen the drug interactions administrative work,such as how to improve the recognition level of the drug interactions problem for government and medicine workers,how to go into overdrive to organize the basic study of the drug interactions,how to reform the performance of clinical pharmacy, establishing the database of the drug interactions,interfering in the ADR of the integrant drug combination,spreading and publicizing the research outcome of the drug interactions actively, guiding the clinical medication and undertaking the propagate education of the drug interactions from the aspect of secure medication.The research of secure medication induced by drug interactions is a system engineering,which requires multitude departments—the national drug surveillance management and the departments of public health and so on to coordinate and give full cooperation to achieve the target.A series of relative policies should be published as soon as possible in our country,at the same time;the agenda should be mentioned early about the people's livelihood problem of secure medication induced by the drug interactions.We should take the available measure to avoid the drug abuse and refrain from the infaust drug interactions initiatively;at last we can save resource and service the human-health preferably.