Jagged1 Protein In Psoriasis, Basal Cell Carcinoma And Skin Squamous Cell Carcinoma Pathogenesis

This paper contains two major aspects:the review of references and the report of experiental study. The review is combined with 3 parts. The first part introduced the basic knowledge of Jaggedl. The second part reviewed the development of psoriasis vulgaris research and the relationship between this development and the notch signal pathway activated by Jaggedl protein. The third part reviewed the clinical and histological characteristics of basal cell carcinoma and skin squamous cell carcinoma and the relationship between them and the notch signal pathway induced by Jaggedl. The experiment studied three commonly seen benign or malignant diseases that were closely correlated with the notch signal pathway induced by Jaggedl protein. The samples of these patients'damaged skin were collected and their Jaggedl protein expression was detected by immunohistochemistry. The effect of this pathway on the pathogenesis of these three kinds of diseases was discussed at last.[Purpose] To discuss the effect of the notch signal pathway activated by Jaggedl protein on the pathogenesis of psoriasis vulgaris, basal cell carcinoma and skin squamous cell carcinoma.[Methods] 1. To detect the expression of Jaggedl protein in the lesions of psoriasis vulgaris, basal cell carcinoma skin squamous cell carcinoma patients as well as normal people by envision method of immunohistochemistry.2. To analyze the optical density of the morphology of stained histological slices. The data were mean optical density and integrated optical density.3. To analyze the data of integrated optical density in each group with SPSS 13.0 statistical software, differentiated by t-test, P<0.05 means the difference was statistically different and P<0.01 means significant different.[Results] The results showed that:1. The expression of Jaggedl protein in the lesions of psoriasis vulgaris patients was higher than that in normal people, there were statistically different between them (P<0.05).2. The expression of Jaggedl protein in the lesions of basal cell carcinoma and skin squamous cell carcinoma patients was significantly higher than that in normal people, there were significant statistically different between them, respectively (P<0.01).3. The expression of Jaggedl protein in the lesions of basal cell carcinoma and skin squamous cell carcinoma patients was higher than that in psoriasis vulgaris patients, there were statistically different between them, respectively (P<0.05).[Conclusions] 1. The overexpression of Jagged1 protein in psoriasis vulgaris patients surgested that this pathway may participate the pathogenesis of psoriasis vulgaris, promoted the pathological proliferation of keratinocytes and dermal papillary blood vessels.2. The overexpression of Jagged1 protein in basal cell carcinoma and skin squamous cell carcinoma patients indicated that this protein may be correlated with the proliferation of malignant tumors of the skin.3. The expression of Jagged1 protein in malignant lesions was higher than that in psoriasis vulgaris lesions showed that this protein correlated more closely with malignancy of the skin.