Feigan Diet Induction Of Apoe-/ - Mice (v Sputum) Lead To Hyperlipidemia And Blood Lipids, Nuclear Factor-¦Êb Protein Expression In Research,

Purpose: This topic wants through the fat Gansu diet to induce the ApoE-/-mouse (to bend down phlegm) to initiate the hyperlipemia and to the blood fats and the blood vessel bast influence research, discusses hyperlipemia's Fu Tan the etiology essence.Method:Dividing the ApoE-/-mouse into 2 groups with the stochastic tables law, similarly divides the C57BL/6J mouse into2 groups, altogether 4 groups, each group of 10. Respectively by the normal feed while the fat Gansu feed feeds. Through biochemistry examination, compared with each group of mouse blood serum in total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) level and aorta blood vessel bast shape change.Result: Feeds 8 weeks later, compares with A group of mouse, B,C,D, each group of mice in TC,TG,HDL-C,LDL-C the aspect have the extremely significance difference(p<0.01), With B,C group compare, D group of mouse in TC, TG, LDL-C the aspect has the extremely significance difference(p<0.01), but in the HDL-C aspect, D group compares with B group, has the extremely significance difference(p<0.01), Compares with C group, the difference does not have the significance(p>0.05). In the diet intervention situation, B, C, D blood vessel NF-кB express aggravates gradually.Conclusion: This research had proven that ApoE-/- (congenital talent insufficiency) may induce Fu Tan (hyperlipemia) occurrence; regardless of the fat Gansu diet may induce Fu Tan to ApoE-/- to the normal mouse (hyperlipemia) occurrence; ApoE-/- and the fat Gansu diet intervenes may induce serious Fu Tan (hyperlipemia) the occurrence together, and the sole factor intervention hastens obviously. Has promulgated Fu Tan is the hyperlipemia Chinese medicine bends down the evil cause of disease theory essence.