Research On The Separation Process Of Hydroxysafflor Yellow A

Safflower yellow pigment is the main pharmacological ingredient of the safflower, and the Hydroxysafflor Yellow A (Hereinafter referred to as HSYA) is the main component of it. HSYA is the new drug for treating cardiovascular and cerebrovascular diseases included in the national drug standards. Now, one of the hot spots is preparing HSYA in the high purity.For providing the material for the follow-up experiment, the safflower extraction is prepared in the optimum conditions by water extraction on the basis of previous research. In this paper, it shows the effect of the extraction temperature, extraction time, extraction times and solid to liquid ratio by orthogonal experiment. In the result, the most important factor of the effection is the extraction time, and then are the extraction times, extraction temperature, and solid to liquid ratio. The extraction time, extraction temperature, extraction times and solid to liquid ratio are 45min,45℃,2 and 1:20 at optimum conditions, respectively.In order to increase the content of HSYA in the safflower yellow pigment, we researched the adsorptive property of 9 kinds of the macroporous resin by the adsorption amount and desorption rate of HSYA and the static kinetics of adsorptive property. The results show that, HPD200A resin has higher adsorption amount and desorption rate of HSYA. And the static kinetics of adsorptive property further shows that the HPD200A resin is suitable for separating and purificating HSYA.The traditional separation of evaporation is mainly based on the different volatility of the different components which needs a large of heat, and it is likely to cause irreversible damage for heat-sensitive material. This paper examines the rejection and the permeation flux of three kinds of nanofiltration membrane for HSYA. The experiment results showed that it can get the most permeation flux and relative lower rejection when using NF270-400 membrane. If we use the NF200-400 membrane and NF90-400 membrane, the rejection was more than 90%, but the permeation flux of NF200-400 membrane was more than the NF90-400 membrane's. So we choose the NF200-400 membrane. This paper improves the reported methods of separation and purification of HSYA. For preparing the HSYA products in high purity and value-added, we discussed the separation process of the combination of macroporous resin, the ultrafiltration and the nanofiltration to the safflower extraction. Experimental results show that the optimum separation process route is the combination of the ultrafiltration, the macroporous resin and the nanofiltration.In summary, this article further definited the process conditions of extracting HSYA. Fing the optimum separation process route by the study of the combination of macroporous resin, ultrafiltration, and nanofiltration for separating and purifing HSYA.