The The Rucl <sub> 3 </ Sub> Catalyst Role In The Oxidation Of Benzyl Alcohol And Dual-indole Methane Derivatives Synthesis Research

The oxidation of alcohols to the corresponding aldehydes or ketones is an important process in organic synthesis.Many traditional reagents for converting alcohols to carbonyl compounds are known, e.g., hypochlorite, chromium(VI) oxide, dichromate, manganese(IV) oxide, permanganate, ruthenium(VIII) oxide, iodosobenzene, N-methylmorpholine (NMO). Because one or more equivalents of these-often hazardous or toxic-oxidizing agents were required, the waste of heavy metals or stoichiometric reagents and the generation of undesirable coproducts damage the environment seriously in bulk-scale reaction. Metal catalyzed"green"aerobic oxidation of alcohols to corresponding carbonyl compounds has been proposed for both environmental reasons and potential utility. The thesis consists of three parts as followings:PartⅠ:ReviewsThis part reviewed the progress in the catalytic oxidation of alcohols. Then The thesis reviewed the metal-catalyzed oxidation particularly from the following subsections, such as (i) ruthenium complex catalyzed system; (ii) palladium complex complex catalyzed system; (iii) other metal catalyzed system; The thesis also summarized of bisindolyalkanes of synthesis.PartⅡ:The catalytic properties of RuCl₃ in the oxidation of benzylic alcoholThe catalytic activities of RuCl₃ for the oxidation of benzyl alcohol were investigated and the optimum conditions for the oxidation were proposed respectively. Then the oxidation of other alcohols with RuCl₃ and oxygen (or air) under the optimum conditions was carried out according to the former reaction conditions. The results show that RuCl₃ is a promising catalyst for the oxidation of benzylic alcohol. With the catalysis of RuCl₃ , most of the benzylic alcohol can be oxidized to the corresponding carbonyl compounds with high conversion and selectivity. The results also reveal that the catalysts shows better catalytic activity for the oxidation of aromatic alcohols which contain smaller and electron-attracting groups in the benzene rings. and a short discussion was carried out according to the oxidation results.PartⅢ:The synthesis of bis(indolyl)alkanes using RuCl₃·3H2O as catalyst under mild conditionsIndoles and their derivatives are known to possess various pharmacological and biological properties including antibacterial, cytotoxic, antioxidative, and insecticidal activities.In this study, we report a facile and efficient procedure for the synthesis of bis(indolyl)alkanes synthesis of bis(indolyl)methanes was carried out by the reaction of indole with benzylic alcohol in the presence of RuCl₃-based GDE...