Study On Clinical Anesthesia For Shumianning, A New Compound Anesthetic In Cats

Ketamine is a dissociative anesthetic, producing a cataleptic state, increasing cardiac output, heart rate, pulmonary artery pressure as a result of an increase in sympatheti c tone. Salivation, mydriasis, and rugurgitaion are increased in animals, slight hypot hermia in cats. Xylazine is aα2-adrenoceptor agonist used as a sedative, analgesic, and muscle relaxant in veterinary medicine. Cardiovascular depression may occur, xy lazine decreases heart rate, cardiac output, produces transient hyperglycemia, causes vomiting in dogs and cats, interferes with temperature regulation. Midazolam is benz odiazepine agent, used as an anticonvulsant, muscle relaxant, sedative, and as an adj unct with anesthetic agents. Midazolam is water-solubility so it can rapid bring anes thesia. The aim of this study was to evaluate the effects of ketamine, xylazine, mid azolam combination——SHUMIANNING on anesthetic quality, respritory and circulat ory systems and the other indexes of physiology in cats used with injections.Experiment I:The Anesthesia Experiment of SHUMIANNING, a New Compound Anesthetic Adminstrated Intramuscularly in CatsObjective:To evaluate the effects of SHUMIANNING on quality of anesthesia clini cal status, erythrocyte physiology, hemorheology, and the liver and kidney function i n cats administraed intramusclularly. Method:8 Cats received SHUMIANNING 0.04 mL·kg-1, IM. Onset time of anesthesia, time to the first movement, time to raise head and time to stand were recorded. HR, RR, RT, blood pressures, SpO2, PetCO 2, blood gas, Heinz bodies, hemorheology, biochemical parameters were performed at pre-determined intervals. Result:Anesthesia with SHUMIANNING was accompanie d by quick, smooth anesthesia period, safety and fast recovery process. During the period anesthesia, apnea, emesis, and salivation were not seen. HR, RR, RT, blood pressures, SpO2, PetCO2, blood gas, Heinz bodies, hemorheology, biochemical param eters were not significantly changed during the anesthesia period (P>0.05). HR, RR, RT were not different from the base value (P>0.05). SO2 was increased significant ly during the anesthesia period (P<0.01). Conclusion:Good anesthetic quality, min or cardiorespiratory and hepatic and renal functional effects, and mild erythrocytic physil ogical and blood rheological effects were obtained when SHUMIANNIG was administrat ed intramuscularly in cats.ExperimentⅡ:The Anesthesia Experiment of SHUMIANNING, a New Compound Anesthetic Adminstrated Intravenously in CatsObjective:To evaluate the anesthetic and physiologic effects of intravenous admin istration SHUMIANNING on cats operated. Method:15 Cats received SHUMIANNI NG combination 0.08 mL·kg-1,Ⅳ. Time to the first movement, time to raise head and time to stand from anesthesia were categorically recorded. HR, RR, RT, SpO2 and PetCO2 were performed at pre-determined intervals. Result:Anesthesia with SH UMIANNING was accompanied by quick, smooth anesthesia period, safety and fast recovery process. During the period anesthesia, apnea, emesis, and salivation were n ot seen. HR, RR, SpO2 and PetCO2 were not significantly changed during the anest hesia period (P>0.05). RT were significantly changed (P<0.05). HR, RR and RT, were different from the base value (P<0.05). SHUMIANNING intravenous administ ration was quicker, shorter recovery and more controllable than intramuscular admini stration. Conclusion:Intravenous administration SHUMIANNING was suited to anest hetize cats with short anesthesia requirement.ExperimentⅢ:Anesthesia Comparison of SHUMIANNING, a New Compound Anesthetic to Telazol in CatsObjective:To compare the anesthetic effects of SHUMIANNING to Telazol combin ation on cats. Method:Cats were divided into SHUMIANNING group (5 cats) and Telazol group (4 cats). Onset time of anesthesia, time to endotracheal intubation an d time to the first movement were recorded. HR, RR, RT, the effects of analgesia, sedation and muscle relaxation were performed at pre-determined intervals. Result: Anesthesia with either SHUMIANNING or Telazol was accompanied by good onset and recovery process. Apnea, emesis, and salivation were not seen in SHUMIANNI NG group, but in Telazol group. HR and RR were not significantly changed during the anesthesia period (P>0.05). RT was significantly changed in the two groups (P<0.05). The effects of sedation and muscle relaxation in SHUMIANNING group were better than Telazol group (P<0.05). Conclusion:Both SHUMIANNING and T elazol meet the requirements of clinical anesthesia for short-time operation in cats. T elazol could reduce tachycardia and SHUMIANNING could inhibite heart rate slightly. SHUMIANNING had better muscle relaxation effect than Telazol.