Comparative Study Of Using Paclitaxel Micropole Drug Coated Stent And Sirolimus Drug Eluting Stents In Primary Percutaneous Coronary Intervention Of ST-Segment Elevation Acute Myocardial Infarction

Objective:To Compare the efficacy and safty of paclitaxel Micropole Drug Coated Stents and sirolimus drug eluting stents in primary percutaneous coronary intervention of ST-Segment Elevation Acute Myocardial Infarction.Methods:105 consecutive patients with STEMI underwent primary PCI were included from October.2008 to April.2010 in NANKAI hospital of TIANJIN.which were divided randomly into two groups.Group Paclitaxelwere treated with paclitaxel Micropole Drug Coated Stents (n=50). While Group Apamycin were implanted domestic rapamycin-eluting stents(n=55).Record the clinical basic material,coronary angiography material, surgical material of the selected patients.Follow-up the two groups of patients through telephone,outpatient service and being in hospital again, Review coronary angiography six months later after PCI.The incidence of major adverse cardiovascular event (MACE),stent thrombosis,the incidence of restenosis,late luminal loss,loss index were evaluated during in-hospital,30 days,6 months,12 months follow up after PCI in patients of two groups. Continuous variables, presented as mean±SD, were compared by unpaired Student's t-test or u-test. Categorical variables, presented as frequency and percentages, were compared usingthe Chi-square test or Fisher's exact test as appropriate.Results:The clinical basic material,coronary angiography material, surgical material of the selected patients were no significant differences.77.1(75/105) patients in the two groups were followed up by CAG,among them 70%(35/50) in the group Paclitaxel and 72.7%(40/55) in group Apamycin.Compared with group Apamycin, the late luminal lost,diameter stenosis degree, lost index has not significantly reduced in group Paclitaxel (P> 0.05).The in-segment restenosis rates of group Paclitaxel is 14.3%(5/35),while10.0%(4/40) ((14.3%vs10.0%, P=0.571) in group Apamycin.There were no acute, subacute and late in-stent thrombosis during hospital stay,30 days,6months,12months followed up in group Paclitaxel,While there was one case of subacute thrombosis in Group Apamycin,no acute and in-stent thrombosis. There were no significant differences in rates of MACE during hospital stay,30 days,6 months,12 months after operation between the 2 groups (P> 0.05).conclusion:During one-year following-up, paclitaxel Micropole Drug Coated Stents is safety and efficacy as sirolimus drug eluting stents in primary percutaneous coronary intervention of ST-Segment Elevation Acute Myocardial Infarction.