| Objective:To research the efficacy and safety of Endostar combined with chemotherapy on malignant tumors.Methods:17 cases of malignant tumors of First Affiliated Hospital of Zhengzhou University from 2009 to 2010 were treated with retrospective analysis to assess the short-term curative effect and toxicity reaction of the combination of recombinant human endostatin with chemotherapy for malignant tumors.Results:Totally 63 cycles were completed and mean cycle was 3.7. Among 17 cases, there were 11 cases achieved PR,5 cases of SD, and 1 case of PD. The response rate was 64.71%(11/17) and disease control rate was 94.12%(16/17); The quality of life were improved on 6 cases (35.29%), stabled on 11 cases (64.71%), and decreased on 1 cases(5.88%). The occurrence rates ofⅢ/Ⅳtoxicities were neutropenia (12/17),thrombocytopenia(3/17) and hepatic dysfunction (1/17).Conclusion:The objective response and QOL of patients with multiple kinds of advanced malignancies may be safely improved by the combination of endostar with chemotherapy. It is worthy of clinical generalization and further clinical observation. However, further observation is needed to evaluate the long-term outcome and adverse reactions. |
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