| Nasal sinus common form a unified, the function of each unit of the mucosa in physiological and pathological continued, which has its generality, so collectively known as nasal sinus department. Malignant tumor generated from nasal cavity and paranasal sinuses is common in otolaryngology. in the whole body in Nasal malignant tumor accounted for about 2.05-3.66 percent; in head and neck cancer accounts for approximately 11.9 percent; in otolaryngology head and neck surgery after nose pharynx, laryngeal cancer within the scope and finishing third, One of the most common is a squamous cell carcinoma, accounted for about nasal sinus malignancy 55.3% Its incidence may be related with the following factors:the long-term chronic inflammation stimulated repeatedly; Long-term contact carcinogenic substance; Benign tumor malignant transformation as inerted papilloma; Trauma and so on。Nasal sinus department tumor good hair at nasal and maxillar sinus. Due to the occurrence of malignant tumor is a including oncogene activation and (or) tumor-suppressor gene inactivation, etc, with many of the genetic mutation, more about the long-term factors are involved in the complex process, nasal sinus malignant tumors is no exception. Domestic and overseas scholars already from anatomy, morphology, and molecular biology, genes of nasal sinus squamous cell carcinoma in the pathogenesis of lots of research, but its exact pathogenesis is still not clearly states, so its pathogenesis is always the focus of attention. Always has a large study shows that, the EGFR receptor family in larynx, swallow, EGFR head and neck squamous cell carcinoma of the tongue, etc may exist among certain function, and PRL-3 in other such as e. squamous cell carcinoma, such as uterine cancer in parts of squamous cell carcinoma, and also presents the high expression, EGFR, PRL-3 both can promote cell proliferation and adhesion, invasive, transfer, thus inducing tumor formation, and PRL-3 in the nasal sinus squamous cell carcinoma of the expressions, never had a research at home and abroad in the nasal sinus PRL-3, the expression of squamous cell carcinoma in how these two factors coordinated promote whether the occurrence of nasal sinus squamous cell carcinoma, and this is the purpose of this trial. The experiments using immunohistochemistry detection EGFR, PRL-3 two molecular markers in the nasal sinus differentiated squamous cell carcinoma of the expression of these two, through molecular biology markers in the nasal sinus squamous cell carcinoma of the expression in combination with clinical pathologic features research and analysis of the nasal sinus, Further explore nasal sinus squamous cell carcinoma of the pathogenesis and the two factors in the role of squamous cell carcinoma, thus make nasal sinus squamous cell carcinoma patients, and their early identification provide guidance.ObjectiveThrough the lier regeneration phosphatase-3, the epidermal growth factor receptor nasal sinus in each squamous cell carcinoma and nasal polyps in comparing the status of the organization, and expressed in every differentiated squamous cell carcinoma of the comparative, and the correlation between each index analysis, the discussion of EGFR, PRL-3 two biological markers in the nasal sinus squamous cell carcinoma on mechanism of molecular biology, and the nasal sinus role with the relationship between differentiated squamous cell carcinoma, thus make patients, and their early identification provide guidance. Materials and Methods1 Subjects30 cases of nasal sinus squamous cell carcinoma tissues and 20 cases of Nasal polyps organization were for zhengzhou university first affiliated hospitals in January 2005-2010 May surgical resection, or biopsy specimens archive wax pieces. (all cases were confirmed by pathology and a complete clinical data). Squamous cell carcinoma of the pathological press differentiation degree is divided into three groups, among which many differentiation of high, medium and low differentiated every 10 cases。All patients were not be preoperative chemotherapy and radiotherapy, any immunotherapy, all organizations were performed HE dyed and determine pathology staging. One male patients, women were 22 cases in 8 cases, age is 9-84, including digits for 53 years old age.20 cases of normal nasal mucosa as control group. For the routine biopsy specimens were again.2 methodExperimental results using the statistical software SPSS 13.0 all data for the data processing analysis. Counting material EGFR and PRL-3 positive number EGFR using a chi-square test, and in the nasal sinus PRL-3 expressed in squamous cell carcinoma in the relationship between 2 inspection by X-ray. P<0.05 said a statistically significant difference (P<0.01) says there is a significant difference of statistical significance3 AssessmentEGFR, PRL-3 slices in at high magnification (both under X 400) each 5 random field of vision counting 500 cells, calculation of positive cells similar numeration cells for positive cells rate, the percentage rate, according to the positive cells are half quantitatively.4 Statistic analysisExperimental results using the statistical software SPSS13.0 all data for the data processing analysis. Using a chi-square test,P<0.05 says difference was statistically significant. Results1. EGFR, PRL-3 in the nasal sinus squamous cell carcinoma, nasal polyps expression:the EGFR excessive positive expression rate respectively is between 0.00% 66.67%, positive, there was significant difference oerexpressed (P<0.05). PRL-3 overly masculine expression rate were 66.7%,0.00%, both between oer-expressed significant positie difference (P<0.05)2. EGFR,PRL-3 in the nasal sinus squamous cell carcinoma of the expression comparison:many differentiation EGFR excessive positive expression rate respectively is 40.0%,60.0%,100.0%,well-differentiated and differentiation, differentiation and low differentiation in no obvious difference between oerexpressed (P>0.05). PRL-3 overly masculine expression rate respectively is 40.0%,70.0%,90. 0%, well-differentiated and differentiation, differentiation and low differentiation in no obvious difference between oerexpressed (P>0.05).3. EGFR, PRL-3 both in nasal sinus squamous cell carcinoma are the expression was positively associated with squamous cell carcinoma of the differentiation degree increase trend. Reduce presentConclusions1. Nasal sinus squamous cell carcinoma patients organization of EGFR, PRL-3 increased by different content may directly cause cell signaling pathways, thus make the cell proliferation continued transformation, may undergo malignant nasal sinus squamous cell carcinoma is the course of illness early events.2. EGFR,PRL-3 in the nasal sinus squamous cell carcinoma tissues with excessive positive expression rate of squamous cell carcinoma of the pathology of differentiation degree of the trend has a gradual increase reduced, but there were no statistically significant, but shall be as evaluation index of degree of malignancy tumor.3. PRL-3 and in the nasal sinus squamous cell carcinoma EGFR in expression that may be positive correlation between both synergy can promote squamous cell carcinomas occur. |
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