The Evaluation On Long-term Effect Of Treatment Of Integrated Lupus Compound Formula Prescription And Western Medicine Of SLE

Objective:The prescription is on the basic of Pass.using including SLEDAI scale and TCMSS scale to evaluate the long-term effect of integrated Chinese and Western medicine on SLE. Register the data of the age.sex.clinical manifestation of onset,routine laboratory data.The effieaey target is to work combined with western medicine,decrease dose of western medicine and lessen the side or toxic effect.There still exit some shortcomings and problems as far as the SLE clinic research just like irrational clinic design and unreasonable adoption of efficacy index are concerned.The research and the result are hard to be accepted by both domestic and international academy. There is short of index of Traditional Chinese Medicine pattern to show advantage of Traditional Chinese Medicine.so we try to find the inherent relationship between SLEDAI and Explore of the Traditional Chinese Medicine syndrome distribution. To observe the curative effect of SLE patients who treated with integrated Chinese and Western medicine regularly. Exploration into the prognostic factors of the regular therapy of combined Chinese and Western medicine.Methods:Use the data of the age,sex,clinical manifestation,routine laboratory data,SLEDAI and TCMSS scles to evaluate. Retrospective.multicenter.control test was adopted to carry out the clinic trials.Divided 600 cases with mild active SLE into A to D groups(150 cases each),Agroup(Treatment Group)treated with integrated Chinese and Western medicine,Bgroup(Control Group)treated with Glueoeortieoid and Cyclophosphamide. Cgroup(Regular Therapy Group)treated with integrated Chinese and Western medicine regularly,Dgroup(Unregular Therapy Group)treated unregularly.Result:1.In this research, different pattern of syndrome has different disease rate.The sensitivity rates of the type of syndrome were(from high to low):Excessive noxious heat type,Stasis-heat accumulate type,Beriberoid pyretic arthralgia type.Deficiency of both vital energy and blood type,Yin asthenia generating intrinsic heat type.Liver-kidney Yin deficiency type,Insufficiency of both the spleen and the kindey type.2.Different pattern of syndrome has different SLEDAI. The SLEDAI of the syndrome were(from high to low):Excessive noxious heat type,Yin asthenia generating intrinsic heat type, Beriberoid pyretic arthralgia type,Stasis-heat accumulate type.Deficiency of both vital energy and blood type.Liver-kidney Yin deficiency type,Insufficiency of both the spleen and the kindey type.3.Long-term effect of integrated Chinese and Western medicine treatment of SLE showed a better result than simple to use Glueoeortieoid and Cyclophosphamide.4.Long-term effect by integrated Chinese and Western medicine regularly showed a better result than treat unregulaily. ConclusionThrough integrated Lupus compound formula prescription and Western medicine for treatment of SLE.it can improve symptom,control disease,enhance life quality of patients with good and long-term effect,and no toxic side effects of drugs.and it is worth further experiments to explore clinical study.