The Expression Of Monitoring Indicators Of Active Ulcerative Colitis In Different Syndromes And In The Clinical Classification

Purpose:To investigate changes of activity monitoring indicators (platelet count, mean platelet volume, C-reactive protein, erythrocyte sedimentation rate) of patients with ulcerative colitis in different syndromes and they relationships with disease severity, thus providing objective indicators for clinical differentiation and providing objective reference for clinical diagnosis and prognosis.Methods:Selecting 72 patients with ulcerative colitis (UC),and according to classification criteria of state "the guiding principles of clinical research on Chinese medicine and new drug", selecting three common syndromes and classificating them into damp-heat syndrome (20 cases), liver-Qi stagnation and spleen deficiency syndrom (18 cases), spleen-stomach deficiency syndrom (34 cases); According to Western diagnostic criteria and state of UC Truelove and Witts classification, classificating the samples into mild, moderate and severe groups:25 cases of mild group,29 cases of moderate group,18 cases of severe group. Collecting fasting peripheral venous blood of patients with ulcerative colitis, using automatic blood cell analyzer to determinate platelet count and mean platelet volume; Detecting CRP by Turbidimetric method of scattered light; using fasting venous blood of 3.8% sodium citrate, and Westgren method to detect ESR. After consolidation of the collected data, using statistical software of SPSS 13.0 for statistical analysis, measurement data as mean±standard deviation (x±s), then using t-test between groups to analyse the relationships of monitoring indicators (platelet count, mean platelet volume, C-reactive protein and erythrocyte sedimentation rate) of active UC patients, the TCM syndrome type and disease severity.Results:1. The expressions of plt, ESR, CRP with UC patients are the highest in the damp-heat syndrome, followed by liver-Qi stagnation and spleen deficiency syndrome, lowest in spleen-stomach deficiency syndrome.The differences of plt, ESR, CRP levels of damp-heat syndrome and liver-Qi stagnation and spleen deficiency syndrome, spleen-stomach deficiency syndrome are statistically significant (P<0.01); The differences of plt,ESR levels between liver-Qi stagnation and spleen deficiency syndrome and spleen-stomach deficiency syndrome are statistically significant (P<0.01), while the difference of CRP level between liver-Qi stagnation and spleen deficiency syndrome and spleen-stomach deficiency is not statistically significant (P> 0.05).2. The expression of MPV is the highest in spleen-stomach deficiency syndrome, followed by liver-Qi stagnation and spleen deficiency syndrome, lowest in damp-heat syndrome. The difference of MPV level between damp-heat syndrome and spleen-stomach deficiency syndrome is statistically significant (P<0.05), while the differences of MPV level of liver-Qi stagnation and spleen deficiency syndrome and damp-heat damp-heat syndrome, spleen-stomach deficiency syndrome are not statistically significance (P> 0.05).3.The expressions of plt, ESR, CRP with UC patients are the highest in severe group, followed by moderate group, lowest in mild group. The differences of plt, ESR, CRP levels of severe group and moderate, mild group are statistically significant (P<0.01); The differences of plt, ESR, CRP levels between moderate group and mild group are statistically significant (P<0.01).4. The expression of MPV is the highest in mild group, followed by moderate group, lowest in severe group.The difference of MPV level of mild group and moderate, severe group is not statistically significant (P> 0.05); And the difference of MPV level between moderate group and severe group is also not statistically significant (P> 0.05).Conclusions:1. The inflammation damage extent of excess syndrome of UC patients appears more significant than the deficiency syndrome; Increased plt, ESR levels can be used as objective indicators in liver-Qi stagnation and spleen deficiency syndrome and damp-heat syndrome; Increased CRP level and smaller MPV level also can be used as the objective indicator in damp-heat syndrome; measured expression of plt, ESR, CRP and MPV in peripheral blood can help TCM syndrome differentiation of UC patients, thus to determine treatment method.2.Plt, CRP and ESR levels of UC patients have significant correlations with clinical activity degree. They can be used as easy and simple references of clinical severity for ulcerative colitis.For guiding diagnosis and treatment, and determining efficacy and prognosis of UC,they may have some better practical significance.3. There is no specificity of MPV level in disease severity of UC; MPV level has little significance for the evaluation of clinical severity of ulcerative colitis.