| PurposeIn order to understand the relationship among personality, CFH and coronary heart disease, we explore the effect of the personality factors-type A behavior patterns and type D personality, and immune complement factors-CFH on coronary heart disease, and then discuss the influence of the interaction of them on that, which would provide theoretical basis of intervention with behavior and immune for coronary artery disease.Methods1. One hundred and forty patients with coronary heart disease were selected into the study from affiliated hospital of Medical College, including 72 cases of men and 68 cases of women. All this patients underwent coronary artery CT or selective coronary angiography, and according to the diagnostic criteria were divided into three groups, stable angina pectoris, unstable angina pectoris and acute myocardial infarction.45 subjects which exclude coronary heart disease with healthy people were selected into the control group, including 20 cases of men and 25 cases of women.2. Use survey questionnaires-general situation questionnaire, type A behavior pattern questionnaire and Type D Personality Scale to assess the basic situation and types of personality of all the participants.3. Use venous blood of all the participants to measure the plasma levels of complement factor H by Enzyme Linked Immunosorbent Assay and the biochemical indicators by biochemical methods.4. All statistical analyses were performed using SPSS version 16.0 to compare measurement data with t test and analysis of variance. Discrete variables were compared withχ2 test. Multivariate linear regression analyses were performed to investigate the impact of personality factors, risk factors of CHD and biochemical indicators in coronary heart disease. A P value of< 0.05 was used for all tests to indicate statistical significance.Results1. We eventually collected valid questionnaires 163 copies. The subjects were divided into four groups,41 cases with stable angina,42 patients with unstable angina pectoris,40 patients with acute myocardial infarction group and 40 normal controls.2. Of 123 patients with CHD,82 (66.7%) were classified as type A behavior pattern, which was higher that in control group (P=0.015), and 49 (39.8%) were classified as type D personality, which was higher that in control group (P=0.022) The proportion of type A behavior pattern among four groups has a statistically significant difference (P=0.002). And there was no remarkable difference in the proportion of type D personality among four groups.3. The scores of TABPQ,TH,CH and NA among four groups had statistically significant differences (P<0.002). And there was no remarkable difference of the score of SI among four groups.4. There were no significant differences in the plasma level of TC, TG, GLU, LDL, VLDL and HDL among the different personality of patients with CHD groups.5. In multivariable analyses, there had statistically significant for age, history of hypertension, HDL and NA. No significant differences were found in gender, TC, TG, GLU, LDL, TH, CH and "AD-type".6. There were no significant differences in the plasma level of CFH among four groups and among the different type of personality groups.Conclusion1. There had correlation between type A behavior pattern and coronary heart disease. 2. The results suggest type D personality were associated with coronary heart disease.3. TH, CH and NA were associated with coronary heart disease but SI was not.4. TC, TG, GLU, LDL, VLDL and HDL may be were not associated with different personalities of coronary heart disease.5. Age, history of hypertension and NA were the risk factors to coronary artery disease, and HDL was the protective factor.6. CFH was not associated with coronary heart disease, and different types of personalities had no effect on plasma levels of CHF. |
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