The Effect Of S100B With Sevoflurane Combined Anesthesia On Patients Undergoing Intracranial Aneurysm Surgery

Objective To observe the effect of hemodynamics and the dynamic change of S100B protein, investigate protective cerebral effects with sevoflurane combined anesthesia on patients undergoing intracranial aneurysm surgery.Methods Forty patients undergoing intracranial aneurysm intervention (ASAⅡ-Ⅲ) were randomly divided into two groups:S (Sevoflurane group) and C (Control group),twenty in each group.In S group anesthesia maintained with 0.5～1.5% sevoflurane combined with a target controlled infusion of propofol and remifentanil, C group maintained with total intravenous anesthesia .ECG,MAP,CVP,SpO2,PETCO2,BIS were continuous monitored during operation. MAP,HR,CVP,BIS were recorded before operation(t1)intubation(t2),skin incision(t3),drilling the skull(t4),aneurysm(t5),sewing skin(t6),extubation(t7).Blood samples were taken from center venous at before anesthetic (T1),aneurysm (T2),'2h (T3),4h (T4),24h (T5) after aneurysm for determination of plasma S100B protein with enzyme-linked immunosorbent assay.Results There is no significant difference between MAP,HR,CVP at time points in the two groups (P> 0.05). MAP was significantly lower than preoperative (t1) (P< 0.05). group comparison:There were no significant differences among the two groups at T,,T2 (P>0.05),the value of S group was significantly lower than that of C group after T3 (P< 0.05); comparison within group:The value of plasma S100B increased significantly after aneurysm (T2) in both groups (P＜0.01), maximu values at T1 (P< 0.01),decreased at T3 Conclusion Sevoflurane compound anesthesia provided satisfactory anesthesia and stabilization of hemodynamic for intracranial aneurysm surgery,and provided better cerebral protective role on patients,which is related to the decrease of S100B protein.