The Clinical Significance Of Plasma BNP In Acute Myocardial Ischemiain

Objective:Study the clinical significance of plasma B-type natriuretic peptide (BNP) changes in acute myocardial ischemia injuryMethods:Retrospective analyse 62 CHD patients who are from the cardiology and emergency department in people hospital of Jilin province during February 2009 to October 2011,34 cases with unstable angina pain, Male 20, Female 14,28 patients with acute myocardial infarction, Male 16, Female 12. When unstable angina acute attack we take the blood samples. Admission in patients with acute myocardial infarction take the blood samples immediately.. Interval of 4-6 hours to take blood samples again, followed by dynamic monitoring of changes in myocardial enzymes in patients with myocardial infarction. All patients were given nitrates to expand coronary artery, aspirin and clopidogrel to resisto blood platelet, heparin anticoagulant, statins regulate lipid, angiotensin-converting enzyme inhibitors, calcium antagonists,β-blockers and other active interventive treatment, when the Symptoms release and hemodynamic stability, take the blood samples and measured again, compared results of the two samples. BNP and troponin I was measured by chemiluminescent immunoassay fat particles, Using U.S. BECKMAN Access2 machine. The normal reference value of BNP was 0-100 pg/ml. The normal reference value of troponin I wae 0-0.06 ng/ml.Results:All patients in the hospital immediately, or the treatment of acute disease has not yet given, and after active treatment, take the plasma BNP and troponin I. The plasma BNP was264.7±11.5pg/ml in unstable angina pectoris patiens, then it reduced to104.6±14.1pg/ml after the treatment. In acute myocardial infarction patients the plasma BNP was 342.8±15.7pg/ml, then it reduced to 132.5±12.7pg/ml after the treatment. The troponin I were all in normal range in each group before the treatment, then presents the dynamic evolution after the treatment in acute myocardial infarction patiets. There was significant difference between before and after treatment (P<0.05).Conclusion:Acute myocardial ischemia is an important factor in the release of plasma BNP. There was significant difference of BNP levels in acute myocardial ischemia patients before and after the treatment. Plasma BNP has an important value in early diagnosis and treatment of acute myocardial ischemia, and to some extent, it reflect the degree of myocardial ischemia.