Unconditional Logistic Regression Analysis To Possible Risk Factors For Central Coordination Disturbance

ObjectiveTo identify possible risk factors for central coordination disturbance(CCD)in children.Materials and Methods1.Totally 225 cases of CCD were collected from the Third Affiliated Hospital of Guangzhou Medical University from January 2006 to December 2010.And 225 cases of sick children with non-CCD and healthy children treated at same period in the hospital were collected as the control.2.The investigation form of sick children with CCD and health children was self-disigned. The investigated items included antenatal, intrapartum and postnatal factors. The antenatal factors included mother's factors, such as educational background, age of delivery, abnormal delivery, sickness or abnormal manifestations in pregnancy(such as pathogen infection, pregnant syndromes and vaginal bleeding);and fetal placents factors, such as neck winding, twin pregnancy. The intrapartum factors included the complications in delivery, delivery ways,fetal distress in uterus, etc. The postnatal factors included various kinds of disorders in neonates, such as neonatal asphyxia, neonatal hypoxic-ischemic encephalopathy and hyperbilirubinemia of newborn, etc. Questionnair of investigation was performed by looking up medical records and inquiring the mothers.3.Unconditional logistic regression analysis was done on single factor and multi-factors. The factors that presented statistical significance in single-factor analysis, significant difference(P<0.05) and P value near to 0.05 were adopted to establish the model of multiple. Unconditional multi-factors logistic regression analysis of main risk of CCD was carried on.Results1.The birth gestation age(33.50±3.54weeks)in the case group was lower than that in the control group(38.67±1.51weeks)(P<0.05). The birth weight (2.00±0.73kg)in the case group was lower than that in the control group(3.18±0.40kg)(P <0.05).2.The results of conditional regression analysis showed that CCD was associated with previous premature, low birth weight, cesarean section,fetal distress in uterus, neonatal asphyxia, abnormal amniotic fluid, premature rupture of membrane, newborn inhalation pneumonia and small for gestational age. Their odds ratios (95%CI) were 24.362 (12.90~46.01),10.472 (4.01~27.36),3.558(2.09~6.07),7.130(2.38~21.38),33.593(9.98~113.12),5.701(2.69~12.10),2.045(1.02~4.11),58.649(16.61~207.05),3.555(1.36~9.32). Unconditional multi-factors logistic analysis showed the risk factors of CCD include previous premature, low birth weight, cesarean section, neonatal asphyxia, abnormal amniotic fluid, premature rupture of membrane and newborn inhalation pneumonia.ConclusionsCCD maybe be related to several risk factors. It is suggested to prevent and eliminate actively various risks of CCD before, during and after delivery (such as previous premature, low birth weight, fetal distress in uterus, neonatal asphyxia, elder age of pregnant mother) so as to reduce the incidence rate of CCD.