The Logistic Regression Analysis Of Fetal ThyroidDysplasia And Maternal Risk Factors

Purpose The logistic regression model was applied to discuss the correlation between fetal thyroid dysplasia and maternal risk factors.It is recommended to screen those meet high-risk factors,aiming to effectively detect the fetal thyroid dysplasia,thus fetuses with thyroid dysplasia can be found and treated in time before birth,avoiding a series of irreversible pathophysiological changes.Methods The present study adopted 148 pregnant women who has conducted obstetric ultrasound examination in our hospital from December 2016 to May 2018.Among them,the 58 cases showed fetal thyroid dysplasia were set as experimental group,and 90 cases of normal fetal thyroid were set as control group.A history of thyroid dysfunction and thyroid surgery,a family history of thyroid disease,goiter,thyroid autoantibodies,clinical signs and signs suggesting high or low thyroid function,type 1 diabetes,as outlined in the Guidelines for Diagnosis and Treatment of Maternal Thyroid Diseases.Other autoimmune diseases,infertility,and other factors such as TSH and TH,head and neck radiotherapy history,abortion and premature birth history based on the Guidelines for the Diagnosis and Treatment of Maternal Thyroid Diseases.Conduct high-risk factors survey for each pregnant woman who is prenatally screened in our hospital.The first-line univariate analysis was used to exclude statistically significant factors.Logistic regression analysis was performed on the statistically significant factors in the univariate analysis.The ultrasound images of the two groups were compared.Results(1)The results of ultrasound image: 148 pregnant women have participated in this study,among them,58 cases showed fetal thyroid dysplasia.90 cases showed normal fetal thyroid.(2)Logistic regression analysis showed five factors were selected:the mother had a history of thyroid dysfunction,thyroid surgery(28 in the experimental group and 15 in the control group),goiter(20 in the experimental group and 6 in the control group),positive thyroid autoantibodies(13 in the experimental group and 9 in the control group),head and neck radiation(14 in the experimental group and 5 in the control group),abortion and premature delivery(19 in the experimental group and 11 in the control group).The results from both groups showed the rate of fetal thyroid dysplasia of maternal thyroid dysfunction history,thyroid surgery,goiter,positive thyroid autoantibodies,head and neck radiation,abortion and premature delivery in the experimental group was significantly higher than that in the control group(P<0.05).The logistic regression analysis suggested that the above-mentioned five factors are high risk factors mainly leading to fetal thyroid dysplasia.Conclusion The results of logistic regression analysis suggest the above-mentioned five maternal high-risk factors were the high-risk factors leading to fetal thyroid dysplasia.