Expression And Significance Of HMGB1 In Oral Cancer And Precancerous Lesions

Objective: The aim of this study is to investigate the expression of HMGB1 in oral cancer and precancerous lesions, and discuss the significance of HMGB1 in the the occurrence and development of tumor.Methods: All specimens were obtained from stomatological center of Tongji hospital of Tongji Medical College, Huazhong University of Science and Technology. Seventy-four cases of oral cancer and precancerous lesions were included in this study. Among these cases, there were 9 samples of normal mucosa, 8 samples of simple hypoplasia, 22 samples of dysplasia and 35 oral squamous cell carcinoma.SP immunohistochemical method was used to investigate the positive expression rates of HMGB1 in paraffin-embedded oral cancer and precancerous lesions.Results: The positive staining of HMGB1was observed in cytoplasm. The positive expression of HMGB1 in normal mucosa was 11.1%(1/9), in simple hypoplasia and dysplasia were 12.5%(1/8),59.1%(13/22)10%, and in oral squamous cell carcinoma was 82.9%(29/35), respectively, the positive rate of HMGB1 in oral squamous cell carcinoma and dysplasia were significantly higher than that in normal mucosa and simple hypoplasia (P<0.000). HMGB1 in oral squamous cell carcinoma of well differentiated and poorly differentiated tissues in the rate difference was not statistically significant (P <0.361), and tumor diameter greater than 3cm was significantly higher than that of the less than 3cm (P < 0.035), expression of tumor metastasis was significantly higher than that without metastasis of the tumor (P <0.016).Conclusion: The different expression between oral cancer and precancerous lesions indicating HMGB1 play a role in tumorigenesis, and HMGB1 in squamous cell carcinoma of the pathological features of the difference on the expression of HMGB1 that has nothing to do with the degree of tumor differentiation, However, in tumor growth, invasion and metastasis.