| Objective:To evaluate the effect of compound a-ketoacid on nutritional status and calcium-phosphate metabolism in maintenance hemodialysis (MHD) patients.Methods:38 MHD patients were randomly divided into therapy group (19 patients) and control group (19 patients) . Two groups were given the same basic therapy, trerapy group were given compound a-ketoacid while control group were given calcium carbonate for 6 months. Serum albumin,pro-albumin,phosphate, calcium, calcium-phosphorus product, iPTH , urea, creatinine and other indicators of changes were measured before and after the treatment. Serum albumin,pro-albumin,serum phosphate,calcium ,urea and creatinine were measured by automatic biochemical analyzer determination, while blood iPTH were measured by application of immune chemiluminescence method. Datas were analysed by SPSS 11.5 statistical software.P<0.05 for the differences were significant.Results:(1) Serum albumin and pro-albumin of therapy group were much higher than before treatment and control group,have significantly statistical significance (P<0.001) . (2) Serum phosphate and iPTH of two groups decreased significantly after treatment, have statistical significance(P<0.05);While the decrease rate has no statistical significance (P>0.05). (3) Calcium-phosphorus product of two groups decreased,but has no statistical significance(P>0.05) . (4)Hypocalcemia of two groups corrected after treatment, the incidence of high calcium levels therapy group is 5.26% and control group is 10.53%,calcium control situation of two groups has no obvious difference .Conclusion:Compound a-ketoacid can improve serum albumin and pro-albumin,reduce serum phosphate and iPTH , correct hypocalcemia , effectively improve nutritional status and calcium-phosphate metabolism in maintenance hemodialysis patients. |
PDF Full Text Request