| Objective:This study will investigate the effect of bone mesenchymal stem cells(MSCs) transplantation on late heart function in patients with heart failure after myocardial infarction, to explore the safety and effectivity of this new method.Methods:From August 2009 to August 2010 total of 30 patients with myocardial infarction and heart failure were selected into Group ischemic heart disease. Then divided them into control group(10 cases, Group A) and intracoronary injection of autologous MSCs group(20cases, Gruop B). The patients in control group only cured with traditional way. While beside cured with traditional way, the experimental group were cured with MSCs transplantation .After transplantation, multifuction electrocardio- monitor was used 24 hours, and examine the 24 hours dynamic electrocardiogram, the brain natriuretic peptide(BNP) after 1 and 3 months. While before transplantation and after 1 and 3 months, 6 minute walk test(6MWT), left ventricular ejection fraction (LVEF), cardiac output(CO) and left ventricular end diastolic dimension of the two group were evaluated.Results:1. Clinical situation compared before and after transplantation: the clinical situation of the Group B obviously improved compared with Group A. 2. Monitor after transplantation: Group B treated with multifuction electrocardio- monitor didn't show obviously cardiac arrhythmia and blood pressure change. The 24 hours dynamic electrocardiogram after 1 and 3 months ,also didn't show new cardiac arrhythmia.3. 6MWT compared before and after transplantation: After 1 month, in group A and B, there was no significant improvement in 6MWT after MSCs transplantation(P>0.05), but there was significant improvement in 6MWT after 3 months(P<0.05). In Group B, after 3 months there was significant improvement compared to1 month(P<0.05). Compared to the Group A, patients in Group B had no significant differences in 6MWT(P>0.05). 4. Echocardiography compared before and after transplantation: In group B there was significant improvement in CO. EF after MSCs transplantation(P<0.05), especially after 3 months(P<0.05). And there was obvious reduction in LVDd(P<0.05). Compared with Group A , group B also has an obvious improvement in heart function after MSCs transplantation (P<0.05), and in 3 months, this efect was more significant. 5. BNP of all patients in Group B compared before and after transplantation: there was obvious reduction in BNP(P<0.05) at 1month post-transplantation, and so was 3 months post-transplantation. But there was no obvious differences between 1 month and 3 months post-transplantation.Conclusion:Autologous bone marrow mesenchymal stem cell transplantation for treatment of heart failure after myocardial infarction is safe and effective.Relative to the line of anti-heart failure drug therapy alone has its advantages, a significant improvement in cardiac function.No early treatment of low cardiac output, severe arrhythmia, immune rejection, infection and cancer and other adverse reactions. |
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