Studies And Bioactivity Research On Chemical Constituents Of Chloranthus Japonicus

This dissertation elaborated the studies and bioactivity research on chemical constituents of the whole plant Chloranthus japonicus which belongs to the family of Chloranthaceae and bioassay on some compounds isolated. From the above mentioned plant, a total of 23 compounds were isolated by the chromatographic methods (including TLC, PTLC, CC, Sephadex LH-20, ODS and HPLC) and their structures were established by spectroscopic methods (including UV, IR, MS, NMR and X-ray). Among them, 6 compounds were elucidated to be new ones. And the research progress on the chemical constituents of the plant and pharmacological action were summarized.Chapter 1 Review on the chemical constituents of the plantChloranthus japonicus and pharmacological action. Compounds(sesquiterpenoids, disesquiterpenoids, lignans, alkaloids, Coumarins, steroids and steroid saponins) from Chloranthus japonicus and main physiological functions of natural products from the plant are reviewed.Chapter 2 Review on Disesquiterpenoids of other plants of ChloranthaceaeDisesquiterpenoids isolated from other plants of the family of Chloranthaceae and their main physiological functions are reviewed.Chapter 3 Studies and bioactivity research on the chemical constituents of Chloranthus japonicusChloranthus japonicus belongs to the family of Chloranthaceae. Its rhizome has used as a treatment for ulcer and piles in traditional medical practice. Some chemical studies have been conducted before. In order to further search bioactive compounds, we investigated chemical constituents of C. japonicus. As a result, six new compounds (1, 7-11) along with seventeen known ones were isolated. These compounds were identified as follows, and their structures are illustrated in Fig. A. Then, some compounds were test for the anti-HIV-1 bioactivity. Among them, shiuzkaol B (15),shizukaol C (22),shizukaol F (12),shizukaol H(18) showed weak anti-HIV-1 bioactivity.