Synthetic Studies On The Paniculatine-type Lycopodium Alkaloids

Lycopodium alkaloids were isolated from the pteridophyta lycopodium and related plants with similar biogenesis. These compounds are present in lycopodium and related species, especially plants of Huperziaceae and Lycopodiaceae. The Lycopodium alkaloids often possess unusual skeletons and promising bioactivity, thus providing challenging targets to synthetic chemists. Direct Aldol reaction is one of the most powerful methods for formation of the carbon-carbon bond. It has attracted much attention in organic synthesis. In this thesis, Aldol reaction, as a key strategy, was used in the synthetic studies on the Paniculatine-type Lycopodium Alkaloids. Three chapters are included in this thesis.In chapter1, We summarized the classification, biosynthesis, biological activities and syntheses of some well-known lycopodium alkaloids, which include Fawcettimine, Magellanine, Magellaninone and Paniculatine.In chapter2, Our strategy analysis including the problems encountered in the course of the synthesis of the target molecules was discussed in details. Two different routes to construction of the tricyclic systems of the Paniculatine-type alkaloids were envisioned, and some key intermediates have been prepared in efficient manner from Pulegone.In chapter3, The experimental procedure and spectum data of intermediate were recorded.