| Plasma lipids refers to all lipids in plasma, it is so called hyperlipemia in the case of the total lipids or part of them go beyond the limit level, and the formal definition is the plasma lipid in abnormity or disorder, i.e. the plasma lipid levels exceed the normal limits. It consists of the serum TC level and TG level and LDL-C level go up, and HDL-C level reduce. With people's living standard increasing, urbanizaion and industrialization, socio demographic and lifestyle have changed greatly, so the middle and old age people's plasma lipids level is becoming higher. Health management were carried out for the middle and old age people in order to monitor, and analysis their risk of chronic disease completely, appraisal their condition of health, and guide their change the unhealthy lifestyle. With the concept of health management, the paper tries to find how to carry out prevention and control of dyslipidemia, explore effective health management system for dyslipidemia, in order to reduce morbidity and mortality of dyslipidemia, lower health care costs, improve nation health conditions. Meanwhile, the paper also has an important reference to the health management of other infectious diseases.Objectivewe analyzed the status of dyslipidemia in general population in a community hospital of Hangzhou trying to find out the reasons and the relationship between living behavior pattern and SNP and dyslipidemia and to find out preventive methods and to provide with rational lifestyle.MethodsIn this study, people aged above40years from a community hospital of Hangzhou were investigated by field survey with questionnaire survey, lifestyle survey and physical examination.497people were included. Statistic data was processed with SPSS13.0software. Canonical correlation analysis (CCA) is a statistical method that can reduce the number of tests by using multiple phenotypes and genotypes in each test. CCA compares two sets of variables (in this case, a set of living behavior pattern and SNP genotypes and a set of lipid levels) to assess the correlation between them. Beside CCA, the effects of living behavior pattern and SNPs variables on each lipid indicators were also calculated by multiple linear regression analyses.ResultsControllable living behavioral factors can determine the level of plasma lipids in male and female population of43.99%and46.87%, respectively. Uncontrollable genetic factors determine the level of plasma lipids in male and female population22.40%and19.88%, respectively. Age factors determine the level of plasma lipids in male and female population22.40%and19.88%, respectively.The factors which had statistical significance for change of TC were physical exercise, intake of vegetable, cream cake, rs174547and rs2156552. When intake of cream cake raised from0/w to5/w, the genotypes of rs174547changed from TT to CC, the male are in higher risk of hypercholesterolemia. When intake of cream cake raised from0/w to5/w, the genotypes of rs174547changed from TT to CC, the male are in higher risk of hypercholesterolemia. When physical exercise more than three times a week, intake of vegetable raised from0～399g/d to400～500g/d, the genotypes of rs174547changed from TT to CC, the female are in lower risk of hypercholesterolemia. But, when the genotypes of rs2156552changed from AA to TT, the female are in higher risk of hypercholesterolemia. The factors which had statistical significance for change of TG were smoking, drinking, physical exercise, intake of cream cake, rs4420638, rs10889353, rs1800588. rs17145738, rs2156552and rs2230806. When smoking, intake of cream cake raised from0/w to5/w, the genotypes of rs4420638changed from AA to GG, rs10889353changed from AA to CC, the male are in higher risk of hypertriglyceridemia. When drinking, the genotypes of rs1800588changed from CC to TT, rs17154738changed from CC to TT, the female are in higher risk of hypertriglyceridemia. When physical exercise more than30minutes one time, the genotypes of rs2156552changed from AA to TT, rs2230806changed from GG to AA, the female are in lower risk of hypertriglyceridemia. The factors which had statistical significance for change of LDL were physical exercise, intake of vegetable, fried foods, rs662, rs3764261, rs174547, rs515135, rs2230806and rs10885393. When intake of vegetable raised from0～399g/d to500g/d, the male are in lower risk of high low-density lipoprotein cholesterol. But, when the genotypes of rs662changed from GG to AA, rs17154738changed from GG to TT, the male are in higher risk of high low-density lipoprotein cholesterol. When physical exercise more than three times a week, the genotypes of rs2230806changed from GG to AA, rs10889353changed from AA to CC, the female are in lower risk of high low-density lipoprotein cholesterol. However, when intake of fried foods raised from0/w to1～4/w, the genotypes of rs174547changed from TT to CC, rs515135changed from GG to AA, the female are in higher risk of high low-density lipoprotein cholesterol.The factors which had statistical significance for change of HDL were physical exercise, rs4846914, rs2230806and rs4420638. When physical exercise three to five times a week, people are in lower risk of low high-density lipoprotein cholesterol. When the genotypes of rs2230806changed from GG to AA, the male are in lower risk of low high-density lipoprotein cholesterol. When the genotypes of rs4846914changed from GG to AA, the female are in lower risk of low high-density lipoprotein cholesterol. When the genotypes of rs4420638changed from AA to GG, the female are in lower risk of low high-density lipoprotein cholesterol.RecommendationCarring out the continuous, effective, economic, convenient, comprehensive, continuous health management in the elderly population, actively, to prevent chronic diseases; Developing the "three class prevention" of dyslipidemia; establish and perfect the comprehensive prevention and treatment net of dyslipidemia; Combianing of the population-based prevention strategy and high-risk prevention strategy. People should establish a correct concept of health and disease prevention. The happening and developing of hyperlipidemia is comprehensive affecting result of lifestyle and genetic factors. Hyperlipidemia will be prevented or controlled if prophylactic measure being took as early as possible. We should quit smoking habit, moderate drinking, establish good eating habits, keep exercise. |
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