Studies On The Preparation Of Camellia Saponin Controlled-Release Tablets And The Stability

In this paper, Camellia saponin used as model drug, preparing Camellia saponincontrolled-release tablets, using broomcorn-stalk, casein, Xanthan Gum and so on asaccessories; Infrared spectroscopy (IR) and scanning electron microscopy (SEM)were used to characterize Camellia saponin controlled-release tablets. In vitro releasecurves of Camellia saponin controlled-release tablets were fit to kinetics equationmodels. The mechanisms of drug release of Camellia saponin controlled-releasetablets were preliminarily studied. The stability of Camellia saponincontrolled-release tablets was also researched. The conclusions were as follow:(1) The camellia saponin controlled-release tablets using broomcorn-stalkcontrolled releases in the acidic dissolve medium. Its formula was as follow: the massratio of three materials per tablet (Camellia saponin: broomcorn-stalk: starch) was266.7:100:33.3, and the diameter of powder of broomcorn-stalk was0.1~0.15mm.(2) The camellia saponin controlled-release tablets using Xanthan Gumcontrolled releases in the distilled water. Its formula was as follow: the mass ratio ofthree materials (Camellia saponin: Xanthan Gum) was240:60, and the tablettingpressure was100kgf/cm2.(3) The camellia saponin controlled-release tablets using casein controlledreleases in the pH=6.8phosphate buffer. Its formula was as follow: the mass ratio ofthree materials (Camellia saponin: casein: Guar gum) was100:90:10, and thetabletting pressure was150kgf/cm2.(4) The camellia saponin controlled-release tablets using HPMC controlledreleases in the distilled water. Its formula was as follow: the mass ratio of threematerials (Camellia saponin: HPMC: sodium alginate) was200:80:20, and5.2mL ofthe90%ethanol (v/v) was employed as adhesives.(5) The drug release mechanism of the camellia saponin controlled-releasetablets using broomcorn-stalk was controlled by anomalous transport and case Ⅱtransport. The drug release mechanisms of other camellia saponin controlled-releasetablets was both case Ⅱtransport.(6) Camellia Saponin, accessories and controlled-release tablets of Camelliasaponin were characterized by infrared spectroscopy (IR). The result showed thatthere were chemical bonds between accessories and Camellia saponin.(7) The electron microscope photographs showed that Broomcorn-stalk and hada lot of cell cavities and holes; Broomcorn-stalk played a storage role of Camelliasaponin. The specific area of the broomcorn-stalk was16.8943m2/g, of which the diameter was0.1~0.15mm. So it is propitious to absorb the drug.(8) The technics of the Camellia saponin controlled-release tablets werereproducibility. The stability of Camellia saponin controlled-release tablets also wereresearched. The results showed that, the stability of Cornstalk-Camellia saponincontrolled-release tablets was poor. High temperature and high humidity had noobvious effect on other Camellia saponin controlled-release tablets during10days,only the linearity of the release was changed. The effect of accelerated testing on therelease of HPMC-Camellia saponin controlled-release tablets was obcious.The subject of innovation was that: This paper prepared Camellia Saponincontrolled-release tablets using powder of Broomcorn-stalk and starch; using thedirect compression and Xanthan Gum, prepare Camellia Saponin controlled-releasetablets; the first time applied the casein to the preparation of Camellia Saponincontrolled-release tablets. It was not only biocompatibility and low toxicity, but alsomutritious.