Rseraches On Photothermal Effect Of The Gold Nanorods With Fluorescent Temperature Nanosensors

Cancer disease is one of the mainly threats to human health. The traditional method of treatment, such as surgical resection, chemotherapy, has high side-effect and is not ideal. Thus, it is urgent to develop new methods and tools. High laser hyperthermia treatment with gold nanorods has relatively mild, non-invasive and little side-effect has aroused wild attention in recent years. However, due to lacking of the standardization, such as the administered doses of the gold nanorods, the powers and time parameters of irradiation, there are still some disadvantages in this method. It brings difficulties for the follow-up study in clinical medicine. Therefore, it is necessary to detect the gold nanorods photothermal therapy in tumor cells for obtaining the optimal treatment parametersEuropium(III) chelates display a large Stokes’ shifts, linear emission, long lifetime and high degree of temperature sensitivity. In this thesis, we study on photothermal effect of the gold nanorods with fluorescent temperature nanosensors.The main contents are as follows:1. Synthetized gold nanorods, whose longitudinal surface plasmon resonance absorption at808nm, in seed-mediated growth method and and modified with polyethylene glycol (PEG).2. Synthetized core-shell fluorescent nanoparticles in an improved reprecipitation method and modified with poly-L-lysine (PLL). We have analysed their biological affinity, temperature-dependent emission and lifetime.3. Based on the fluorescenct Eu-DT nanoparticles, the gold nanorods photothermal in vitro and in vivo have been studied and the datas on the gold nanorods photothermal thearpy in tumor cells have been obteined.