Preparation Of Indomethacin/Cu/LDPE Porous Composite And Its Drug Release Performance

Samples of the IDM/Cu/LDPE porous composite are prepared by a combination oftechniques involving injection molding, particulate leaching, IDM solution incubating,and solvent vacuum drawing. Then the structure of the porous composite is characterizedby kinds of analysis methods. The hydrophilicity and release property of the porouscomposite are investigated.The structure of the porous composite is characterized by X-ray diffraction (XRD),scanning electron microscopy (SEM), X-ray energy dispersive spectroscopy (EDS),Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). Resultsof structure characterizations of these prepared samples show that the IDM/Cu/LDPEporous composite is obtained successfully and it is only a simple hybrid of IDM, copperparticles and LDPE, and both the IDM and the copper particles are generally distributedhomogeneously in its porous LDPE matrix. Two kinds of pore morphology can beobtained by different injection temperatures. And the porosity of the IDM/Cu/LDPEporous composite increases with the increasing of content of DTBHQ.The properties of cupric ions release and IDM release are characterized byAbsorbance measurement. Results of IDM-loaded and release properties of these preparedsamples show that the amount of loaded-IDM increases with the increasing of introducedporosity, and the release rates of both IDM and cupric ions increase with the increasing ofporosity for these prepared samples with the same25wt.%of copper particles. Two kindsof injection temperature have no obvious effect on the release properties. For a certainporosity, the amount of loaded-IDM increases with the increasing of drug loading time.And it shows a faster release rate of IDM and a slower release rate of cupric ions for alonger drug loading time. It indicates that this novel porous composite not only can controlits release of IDM, but also can control its release of cupric ions, its release properties canbe regulated easily by controlling its amount of introduced porosity and the time of drugloading process.