Optimization Of Erythromcin Ethylsuccinate Synthesis Process With Cost Management Concept

During the Erythromycin Ethylsuccinate production process, take erythromycin thiocyanate and succinic acid ethyl ester single cinnamyi chloride as the starting material, and THF to mixed solution for solvent, after the desulfurization reaction and acylation reaction to get the Erythromycin Ethylsuccinate crude products. And after the refined, centrifugal, drying, crushing, mixing, packaging process, the Erythromycin Ethylsuccinate API is obtained.This paper based on the cost concept of ZJATK production Erythromycin Ethylsuccinate API production process improvement for the corresponding research, mainly through Erythromcin Ethylsuccinate desulfurization reaction in the analysis, to join the desulfurization reaction of phosphoric acid hydrogen potassium and potash as the chemical properties of the contrast, there are two potassium, certain concentration solution of the pH value is relatively close.The original process of concentration of12%hydrogen potassium phosphate solution was slow granule, adjust the reaction system pH value, control pH value between7-8.5, to avoid the happening of the hydrolysis side effects. The concentration of50%of potash solution as the desulfurizer, in the reaction process of erythromycin thiocyanate off thiocyanate, analyze the erythromycin and succinic acid ethyl ester single cinnamyi chloride in the esterification reaction. Erythromycin in aqueous solution is not stable, easy decomposition, time too short, the response was not completely, time is too long, and easy decomposition, cause yield drop, and because the erythromycin contains lactone and shrink the structure of testosterone, also have multiple hydroxyl, easy to hydrolysis and increase side effects, impurities, increase, cause the follow-up of crystallization separation increased the difficulty. So should control a reasonable reaction time. Through the research and after lab orthogonal experiment design, find the optimum process conditions of desulfurization reaction.Through the process, we can determine the concentration of20%of potash solution either as a slow granule and can be taken as the desulfurizer, it already maintained the stability of the reaction system, and made the reaction time reduced by half, and get a qualified products. It was also20%of potash use solution try to repeat, purified the dosage of the water was only23.1%, greatly reducing the sewage disposal.It has improved the process of the finished product quality, total yield and the craft, without any increase in potash dosage, under the premise of cancelled phosphoric acid potassium hydrogen, and raw material costs dropped dramatically. And reaction time is shortened, reduce power consumption and cost of artificial. The cost of production per kg can save20yuan, according to the annual output of50tons of industrial production calculation, every year can save cost about1million yuan.All in all, the process improvement not only cancelled phosphoric acid potassium hydrogen the dosage of the purification and reduce the dosage of the water, but also shorten the reaction time, and can produce qualified Erythromycin Ethylsuccinate products. Realize the guarantee product quality, reduce production cost, energy conservation and emission reduction, thus increasing the economic benefit and social benefit.