Preparation Of Mesoporous Silica Nanocapsules And Titanium Dioxide Nanoparticles For Biomedical Application

Mesoporous silica nanoparticles (NPs) with regular pore structure, easily surfacemodification, good biocompatibility, large interior space, and low toxicity have been widelyused in biomedical field. Especially，the transportation of anticancer drug, fluorescenceimaging, magnetic resonance imaging using mesoporous silica NPs have attracted a lot ofattention. Mesoporous titania nanomaterials with strong photocatalytic properties have beenstudied. Because of the photosensitivity, titanium dioxide has been used in the cancertreatment, which is still at the exploratory stage, but has a good theoretical value and practicalsignificance.In this paper, the spherical hollow mesoporous silica nanocapsules were prepared and itsapplication was studied in anticancer drug delivery. During the synthesis process ofmesoporous silica nanocapsules, dye molecules were encapsulated to give the nanocapsulesthe fluorescence characteristic, which can also be used for fluorescence imaging. Moreover,the monodisperse rhombic mesoporous titanium dioxide NPs with uniform size weresuccessfully synthesized by the hydrolysis of tetrabutyl titanate in ethanol, the size ofas-prepared NPs can be controlled by adjusting the amount of tetrabutyl titanate. Afterrepeated experiments, we identified the optimal synthesis conditions. The synthesis method ofmesoporous titanium dioxide NPs was simple, easy operation and low cost. The as-preparedNPs were studied in drug delivery, and the experiments confirmed that the NPs not onlyloaded a lot of drug, but also achieved a sustained release of drugs. Therefore, we believe thatNPs will have a good prospect of application in the treatment of cancer.