Study On Synthesis And Properties Of The Copolymers Derived By Allyl Ammine

Hyperlipidemia has been a threaten for healthy for many years, and it is belived that cholesterol raise result in Hyperlipidemia. Bile acid sequestrant, a kind of widely used lipid-lowering drug,it may chelate with bile acid in intestine to promote excretion, so increase cholesterol transform to bile acid, then concertration of cholesterol in blood decreased. According to the structure of the bile acid sequestrant on sale and in research stage, structural features of potential BAS in general comprise of an optimum combination of charge density, hydrophobic, and water swelling properties. According to this,three kind of copolymers are synthesized:(1) The copolymers PAH/DMDAAC were synthesized by the copolymerization of allylamine hydrochloride (AH) with N,N-dimethyl-N,N-diallyl ammonium chloride (DMDAAC). The structure,thermal stability and molecular weight of PAH/DMDAAC were characterized by1HNMR, infrared spectroscopy thermogravimetric analysis and stastic light scattering. The aggregation behavior of PAH/DMDAAC in aqueous solution were studied by resonance scattering spectral measurements.. The interaction between PAH/DMDAAC and bovine serum albumin in aqueous solution were studied by fluorescence and circular dichroism(CD) spectra. The chelation of copolymer with bile acid in solution were measured by UV-Vis with the method of futural colorimetric.(2) N-octane allylamine hydrochloride (OAH) was obtained by reaction of n-bromooctane with allylamine and then neutralized with hydrochloride. The copolymer POAH/DMD AAC were synthesized by the copolymerization of N-octane allylamine hydrochloride (OAH) with N,N-dimethyl-N,N-diallyl ammonium chloride(DMDAAC). The structure,thermal stability and molecular weight of POAH/DMD AAC were characterized by1HNMR, infrared spectroscopy, thermogravimetric analysis and stastic light scattering. The aggregation behavior of of POAH/DMD AAC in aqueous solution were studied by dynamic light scattering. The interaction between POAH/DMD AAC and bovine serum albumin in aqueous solution were studied by fluorescence and circular dichroism spectra. The chelations of these copolymers with bile acid were measured by UV-Vis with the method of futural colorimetric.(3) The cross-linked polymers were prepared by the copolymer of allylamine hydrochloride with triallylamine hydrochloride. The structure of this copolymer was confirmed by Infrared spectroscopy and thermogravimetric analysis. The solution properties of the cross-linked polymers by resonance scattering spectral measurements. The chelation of copolymers with bile acid in solution were measured by UV-Vis and colorimetric method.