Nickel-Catalyzed SP~2C-Cl Band Activation And The Synthesis Of New Organic Fluorides

Organic chlorides has been widely used in many industrials such as chemical, pharmaceutical, leather, electronics, chemicals, which leads to a mass of chlorine compounds and intermediate products that generated. In the process of synthesis being emitted into the environment. Organic chlorides with various kinds of toxicities. such as carcinogenic, teratogenic and mutagenic characteristics being confirmed, have posed a serious threat on human society and natural environment; Organic fluoride now gradually replacing organic chloride is widely used in the field of emerging, playing an increasingly important role. The C-CI bond activation and synthesis of new fluoride under the action of transition metal has become a hotspot in current researches.This experiment by chlorine schiff base for the substrate syntheses new org., fluoride containing trifluoromethyl(TEF), which using Negishi coupling reaction. Negishi coupling reaction can occur under the catalysis.of Nickel complexes supported by trimethyl-phosphine. We have successfully optimized the optimum reaction conditions for the reaction and speculated the reaction mechanism through this experiment.12kinds of new organic fluoride model were synthesized catalyst as well. Besides, we have also explored the activation of the Chlorobenzene carbon chlorine bonds as well as trifluorometylation. What’s more, we have made the activation of the N-H bonds and coupling reactions of C-N bonds which using the catalysis of Nickel complexes supported by trimethyl-phosphine come true.