The Clinical Study About The Effects Of Fasudil On Nitric Oxide, Endothelin-1and Pulmonary Artery Systolic Pressure In Patients With Chronic Pulmonary Heart Disease And Right Heart Failure

Objection：To observe the effects of fasudil on Nitric oxide,Endothelin andpulmonary artery systolic pressure in patients with chronic pulmonary heart diseaseand right heart failure.Methods：Sixty subjects with diagnosis of chronic pulmonary heart disease andright heart failure in hospital patients were randomly recruited from Mrach2011toMarch2012. All of the patients in accordance with respiratory diseases branch ofChinese Medical Association and the National COPD diagnosis and treatment ofpulmonary heart specification Collaborative Group diagnostic criteria for chronicpulmonary heart disease and13edition of "Practice of internal" diagnostic criteria forchronic right heart failure. The patients were randomly divided into two groups:contrast group(n=30case), treatment for Oxygen, anti-infection, bronchial diastolicagent, improve ventilation, eliminating phlegm, small doses of strong heart,diuresis;Test group(n=30case), treatment for the same antihypertensive drugs and withfasudil60mg intravenous drip,once per day,for14days;Meanwhile thirty normalsubjects were selected. The NO,ET-1,PASP levels in serum were measured in eachgroup. SPSS17.0statistical were used for analysis. P <0.05was considered as asignificant difference.Results：1. Compared with healthy control group,the levels of ET-1,PASP weresignificantly higher and the level of NO was significantly lower in patients withchronic pulmonary heart disease and right heart failure (P <0.05).2.Before treatment, the levels of NO,ET-1,PASP in the treatment group andcontrol group had no significant difference (P>0.05). After treatment, the levels of ET-1, PASP reduced in the two groups (P <0.05),but the experimental group reducedeven more significantly(P <0.05);After treatment, the level of NO increased in thetwo groups (P <0.05),but the experimental group increased even more significantly(P<0.05).Conclusions: The levels of ET-1, PASP in chronic pulmonary heart diseaseand right heart failure were higher than healthy people,the level of NO was lower thanhealthy people; Fasudil significantly reduced the levels of ET-1,PASP and increasedthe level of NO in patients with chronic pulmonary heart disease and right heartfailure.