Related Research Between Ambulatory Arterial Stiffness Index,Microalbuminuria And The Extent Of Coronary Artery Stenosis

objective: To evaluate the relationship between microalbuminuria (MAU)，Ambulatory Arterial Stiffness Index (AASI) and the severity of coronary arterystenosis. The purpose of this study is to provide rationale for the prevention andtreatment of coronary heart disease.Methods: One hundred and eighty patients were randomly assigned.All patientsunderwent coronary angiography. MAU wasdetermined with radioimmunoassay(RIA).Aortic systolic blood pressure (SBP) and diastolicblood pressure (DBP) weremeasured during the period of coronary angiography. All subjectsunderwent24-hABPM after coronary angiography. Brachial SBP and DBP were measuredbefore andafter coronary angiography. The severity of coronary artery stenosis was evaluated bythe number of impaired arteries and Gensini score.Result:(1) Selected cases of the general clinical features of45cases of single vesseldisease group,28males and17females；Double vessel disease in47cases,31malesand16females；3lesions in40cases,26males and14females. Coronary heartdisease group and normal coronary group age, sex，BUN，and Cr，UA，BMI，all P>0.05，have no significant difference.(2)CHD patients in the hypertensiongroup,97cases,35cases of non-hypertensive group, the difference was statisticallysignificant (P <0.01). Patients with CHD, double, three coronary artery diseaseprevalence in the hypertensive group was significantly higher than non-hypertensivegroup.(3) AASI is positively correlated with age (r=0.428，P<0.05). The AASI inwomen is0.45±0.13, and the AASI in men is0.42±0.16. There is no statisticallydifference between them (P>0.05). There is no correlation between AASI and BMI incoronary heart disease (P>0.05).(4) AASI of three-vessel lesion group is the highest(0.66±0.14), followed by two-vessel lesion group (0.51±0.15). AASI of single-vessellesion group is the lowest (0.36±0.14). Any two groups of them is statisticallydifferent (P<0.05).(5) MAU of three-vessel lesion group is the highest（92.5±21.6） mg/L, followed by two-vessel lesion group（69.6±19.3）mg/L. MAU of single-vessellesion group is the lowest（35.8±14.3）mg/L. Any two groups of them is statisticallydifferent (P<0.05).(6) There is no correlation between AASI and MAU in coronaryheart disease (P>0.05).(7) Patients with coronary heart disease indicators do Logisticregression analysis showed that: The result of AASI,MAU is P <0.05，B>0，Exp (B)>1，Suggesting that they are independent risk factors for coronary heart disease.(8)Gensini score of coronary heart disease patients have positively correlated with AASI（r=0.647，P<0.01）；Gensini score of coronary heart disease patients have positivelycorrelated with AASI（r=0.733，P<0.01）.Conclusion: In patients with coronary heart disease, AASI is not associated withMAU,AASI is positively correlated with age and it increases with age. AASI and theMAU level of the CHD group was significantly higher than that of control group.AASI and the MAU level rise with the increase in the number of coronary lesions.AASI and the MAU level was significantly positively correlated with the Gensiniscore, which suggesting that AASI and the level of MAU help discrimination on theextent of coronary artery stenosis.