An Association Analysis Between5-HTR2C Rs518147Polymorphism And Obsessive-compulsive Disorder In A Chinese Han Population

Objective:To investigate the association between obsessive-compulsive disorder(OCD) and rs518147polymorphism in the promoter of the serotonin2C receptor gene(5-HTR2C) in Chinese Han population.Methods:Direct sequencing technique was used to analyse the frequencies of rs518147polymorphism of5-HTR2C hemizygote (male) and genotype (female) in308patients (OCD:123male,185female) with OCD diagnosed according to Chinese classification of mental disorders (CCMD-3) or International Classification of Diseases-10(ICD-10) criteria and410control (Control:175male,235female) and then a case-control association analysis was performed with SPSS13.0.Results:The study group were more likely to be G hemizygote (for male) and G+(GG and GC) genotype (for female) than the control group(male:χ2=4.973, P=0.026; female: χ2=5.243, P=0.022). The study group were more likely to take G allele (χ2=4.611, P=0.032) than the control group.Conclusions:Our results indicated that the rs518147polymorphisms in the promoter of5-HTR2C may play a major role in the genetic predisposition to OCD in Chinese Han population.