The Study Of Type2Diabetes Excessive Fire Injury Qi And Yin Pathogenesis

The study of Type2diabetes excessive fire injury qi and yin pathogenesisType2diabetes mellitus (type2diabetes mellitus, T2DM) in the worldwide incidence of gradually increased. Chinese medicine has unique advantages in the prevention of T2DM. Master of type2diabetes certificate to designate the distribution and evolution reveal the changes in its pathogenesis, in order to find the targeted treatment has important significance.(1) PurposeIn previous studies, we found that type2diabetes from insulin resistance to the development of islet β cell damage, the traditional Chinese medicine syndrome theory is very similar manifestations and pathogenesis of change and the theory of "excessive fire consuming qi", The purpose of this study Investigation and Analysis of type2diabetes syndrome distribution laws, to explore its main syndromes, with "excessive fire consuming qi" theory of pathogenesis-related syndrome; by telling the fed GK rats, two diabetic model, and prepared under the guidance of "excessive fire consuming qi" theory of pathogenesis of Coptis ginseng model animal studies of drug treatment the treatment of type2diabetes, protect the mechanism of action of the pancreatic beta cells, and then explore the"excessive fire consuming qi"the objectivity of the theory of pathogenesis.2MethodsSort through the2003to2010, the medical record, Dongzhimen Hospital, Dongzhimen Hospital in patients with T2DM database. A total of2743patients with T2DM and its complications, a statistical analysis of cases of selected cases met the inclusion criteria of TCM diseases and TCM syndromes. About the name of the main disease of Chinese medicine and TCM syndromes in the name of the frequency and percentage analysis. For count data using the χ2test.For further study in the medical research on the mechanism of the strong fire fresh air "theory T2DM, zoology experiments to study the research the Coptis ginseng on the damage mechanism of the drug on pancreatic β cells. The spontaneous diabetic GK rats to establish the pathological model group and Coptis ginseng drug treatment group, while the establishment of normal Wistar rats in the control group. Given the Coptis ginseng drug treatment group and the pathological model group given high fat diet, the normal control group was given normal diet. Rats in each group, body weight, blood glucose were measured. The end of the treatment of abdominal aortic blood and isolated from the pancreas, were obtained from each group, serum insulin levels, serum C-reactive protein and serum tumor necrosis factor-α levels. Each rat pancreatic tissue of HE staining to observe the rat pancreatic islet β cell apoptosis; group of rats by immunohistochemical staining, and observation of TNF-a within the pancreatic tissue of rats in each group, BAX and BCL-2levels.3ResultsThe "excessive fire consuming qi" theory is leading to T2DM etiology and pathogenesis of Chinese medicine theory. Yin Deficiency, Qi deficiency and heat card is waiting for inclusion in the main cases of TCM. GK rats with fasting blood glucose was not obvious, significantly increased glucose-stimulated glucose is the ideal non-obese type2diabetic rat model. The Coptis ginseng drugs can significantly reduce diabetic GK rats, glucose-stimulated glucose, serum glucose levels. The Coptis ginseng on drugs can reduce the serum of type2diabetic GK rats and islet TNF-a levels, increase protein expression of BCL-2gene in its islets, lower BAX protein expression in islets. The the Coptis ginseng may be the mechanism of drug treatment of diabetes and content regulation of serum TNF-a in islets, and islets within the BCL-2and bax and content related to.