| Objective: To determine carotid elasticity by E-Tracking while take carotidartery as the “window” and establish the indicators for evaluating cerebral arteryelasticity by TCCD and to provide objective basis for diagnose cerebralarteriosclerosis quantitatively.Methods: Group A:120subjects were in control group aged26-60yearswith the average age of42.8±10.77years and68males among them. Bloodpressure, blood lipid, blood glucose and ECG were normal.120patients were in abnormal carotid elasticity group aged30-80years withthe average age of52.9±13.50years and65males among them. All the120patients were divided into the following four groups.Group B: No.1high risk group: Subjects without thickening in intima mediathickness (IMT) of the carotid artery but suffered from one or more ofhypertension, hyperlipemia, diabetes and coronary heart disease.Group C: No.2high risk group: Subjects without plaque in carotid artery butwith thickened IMT and suffered from one or more of hypertension, hyperlipemia,diabetes and coronary heart disease.Group D: No.1group with plaque in carotid artery: Subjects with plaque andthickened IMT in carotid artery but without any clinical manifestations ofhypertension, hyperlipemia, diabetes or coronary heart disease.Group E: No.2group with plaque in carotid artery: Subjects with plaque andthickened IMT in carotid artery and one or more of hypertension, hyperlipemia,diabetes and coronary heart disease.Applied technology: SSD-α10Colorful Doppler Ultrasound produced byAloka in Japan was used. Common carotid artery intima-media thickness (CCA-IMT), plaque in carotid artery, systolic diameter (Ds), diastolic diameter(Dd), arterial stiffness parameter (β), elasticity coefficient (Ep), arterialcompliance (AC) and pause wave velocity (PWVβ) of subjects in control groupand case group were detected in resting state with the sensor frequency of7.5~13.0MHz. TCCD cerebral artery detection: peak systolic velocity (Vp), peakdiastolic velocity (Vd), mean velocity (Vm), pulsatility index (PI), resistanceindex (RI), ratio of systolic and diastolic (S/D), peak time delay of subjects incontrol group and case group were detected by SSD-α10Colorful DopplerUltrasound produced by Aloka in Japan with the sensor frequency of4.0MHz andchanges in cerebral arterial blood spectrum should be observed. The data wasanalyzed combining with clinical and laboratory results, such as age, bloodpressure, fasting blood glucose and blood lipid. SPSS15.0software package wasapplied. IndEpendent sample t-test was used to compare means between twogroups and spearman related coefficient was used to determine the correlationbetween indicators accordingly.Result： Results the control group and the carotid artery elasticity abnormalgroup elastic parameters comparison results show: group A and B group of β, Ep,AC, P <0.05, PWV β>0.05; A group of group C and β, Ep, AC, P <0.01, PWV β>0.05; Group A and D group; Group A group E and β, Ep, AC, PWV β, P <0.01;Group B and C group, the group D group E and β, Ep, AC, PWV β, P <0.05;Group B and D group; Group B and E group, the group C and E group of β, Ep,AC, P <0.01, PWV β <0.05; Group C and D group of β, Ep, AC, PWV β <0.05;The results showed that: in group A, B group, the group C，D， E group betweengroup, along with the carotid artery elasticity reduce β, Ep is higher, AC graduallyreduce, PWVβ beta can be A group with no obvious difference between group B,C, D, E group between group;2. Abnormal carotid artery elasticity of higher thannormal control group Ds, a significant difference P <0.05; Abnormal carotidartery elasticity of higher than normal control group Dd, there were significant differences (P <0.05);3. The carotid artery normal each age group is the timewhen the peak treads time:20-30years old and30-40years old,30to40years oldand40-50years old,40-50and60years old or above all age groups when peaktime there was a significant difference treads ratio (P <0.05);3. The carotid arteryelasticity in abnormal each age peak time delay is:30to40years old and40-50years old,40to50years old and50-60years old,50-60years old and60-70,60-70and70-80years old when the peak age group have significant differencetreads time ratio (P <0.05);4. The carotid artery anomalies and brain arteryelasticity of the reference ratio: group B and C group when peak time ratio treadsare significantly different P <0.05; PI, RI, S/D ratio no significant difference inthe P>0.05; Group C and D group peak time when a little more significant P <0.01, PI, RI, S/D have significant difference (P <0.05); Group D group E withlittle time when peak ratio, PI, RI, S/D more significant difference (P <0.01);4.When the peak time and carotid artery elasticity little correlation comparison: peakdelay, the carotid artery elasticity of the correlation analysis, analysis and Ep, Bmoderate are related, and AC moderate negative correlation, and PWVBcorrelation was weak in the negative. PI value and carotid artery between elasticparameters correlation was weak. RI values and carotid artery between elasticparameters correlation was weak. S/D value and carotid artery between elasticparameters correlation was weak.Conclusions:1. Elasticity coefficient (Ep), arterial stiffness parameter (β) and arterialcompliance (AC) were sensitive indicators for evaluating carotid elasticity withoutmorphological changes and they could be used for early evaluation of carotidelasticity.2. Carotid elasticity parameters were correlated with peak time delay andpeak time delay could be used as quantitative indicator for evaluating cerebralartery elasticity. 3. Peak time delay became longer as the changes of carotid elasticityparameters increased and peak time delay could be used as the indicator toevaluate the reduction of cerebral artery elasticity.4. Statistical analysis: resistance index (RI), pulsatility index (PI), ratio ofsystolic and diastolic (S/D) were not correlated with carotid elasticity parametersand researches on whether RI, PI and S/D could be used as the indictors todiagnose clinical cerebral artery elasticity should be carried out furtherly. |
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