The Expression And Correlation Of E-cadherin、β-catenin And CyclinD1 In Gallbladder Carcinoma

Gallbladder cacrinoma is a highly malignant gastroenteric tumor with Poor Prognosis anddifficult diagnosis in early stage. So，it has very important clinical significance to find newtnmormarker, to diagnosis、therapy and prognosis of gallbladder cancer.Objective: The experiment to explore the expression of E-cadherin、β-catenin and cyclin D1 ingallbladder carcinoma、gallbladder adenoma and cholecystitis，accoding to the result analysis thecorrection between three targets and its clinical significance，Thus for gallbladder diagnosis andtreatment start a new way。Methods: The expression of E-cadherin、β-catenin and cyclin D1 were detected withimmunohistochemistry (SABC) in gallbladder carcinoma,gallbladder adenoma aand cholecystitis.To apply SPSS19.0 statistical software to analyze the experimental data.Results:（1）The expression rate of E-cadherin in the gallbladder carcinoma(37.9％)notable lowthan that in gallbladder adenoma(66.6％) and cholecystitis(68.4％). The abnomal expression rateofβ-catenin in the in the gallbladder carcinoma(63.8％) notable higher than that in gallbladderadenoma(33.3％) and cholecystitis(46.2％). The expression rate of cyclin D1 in thegallbladder carcinoma(59.0％) notable higher than that in gallbladder adenoma(33.3％) andcholecystitis(26.3％)（.2）The expression of E-cadherin andβ-catenin in gallbladder carcinoma issignificantly related with tumor invasion metasis，differentiation degree and clinical stage oftumoror according to Nevin(P＜0.05) and not related with patient’s age、sex (P＞0.05)；Theexpression of cyclin D1 in gallbladder carcinoma is significantly related with differentiationdegree and clinical stage of tumoror according to Nevin(P＜0.05)，not related with patient’s age、sex and tumor invasion metasis (P＞0.05).（3）the expression of E-cadherin andβ-catenin incarcinoma of gallbladder is negative correlation(r=-0.298 p<0.05) .the expression of E-cadherinand cyclin D1 in carcinoma of gallbladder is negative correlation(r=-0.320 P＜0.05). theexpression ofβ-catenin and cyclin D1 in gallbladder carcinoma is positively correlation(r=0.270P＜0.05) .Conclusion: E-cadherin、β-catenin and cyclin D1 plays an important role in the genesis and progression of gallbladder carcinoma . To detect the expression lever of E-cadherin、β-cateninand cyclin D1 could be used as an indicator for prognosis,malignancy degree and clinical stageof gallbladder carcinoma.