| Objective To evaluate the expression of E-cadherin and β-catenin in gastric cancer and to examine the relationship of their expressions with various clinicopathological parameters and patient survival.Methods In this study, we conducted an immunohistochemical investigation of E-cadherin and β-catenin in 119 gastric cancer patients.Results Abnormal expression of E-cadherin and β-catenin were found in 51.3% (61/119) and 76.5% (91/119) of the tumors, respectively. E-cadherin and β-catenin expression were preserved in 48.7% (58/119) and 23.5% (28/119) of cases, respectively. Abnormal expression of E-cadherin with loss of membranous immmunoreactivity was demonstrated. Abnormal expression of β-catenin with loss of membranous immmunoreactivity or cytoplasmic or nuclear staining was observed. Abnormal expression of E-cadherin correlated with poor differentiation, depth of invasion, lymph node metastasis. E-cadherin expression did not correlate with the patient's age, sex, TNM stage. Abnormal expression of β-catenin correlated with poor differentiation, lymph node metastasis, TNM stage. β-catenin expression did not correlate with the patient's age, sex, depth of invasion. Abnormal expression of E-cadherin and β-catenin correlated with poor survival.Conclusion Abnormal expression of E-cadherin and β-catenin was observed in a considerable proportion of gastric cancer. E-cadherin and β-catenin play an important role in the infiltration and metastasis of gastric cancer, and they may be...
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