Microalbuminuria And Endothelial Function, That Relationship With Left Ventricular Damage In Essential Hypertension Abstract

Objective:To study the relationship, that between Left Ventricular Damage and Microalbuminuria、Endothelial function in Essential HypertensionMethod:Select200out-patients and in-patients with Left ventricular damaged, among the age from60to75, from October2009to October2011(Merger of left ventricular hypertrophy groups:47cases; Left ventricular systolic function decline groups:58cases; Left ventricular diastolic function to drop groups:61cases), the same age range from simple35cases hypertension patients for the control group. All conventional measure blood pressure, weight, height, body mass index (BMI); monitor the plasma endothelin-1(ET-1)、Creatinine (Cr), blood urea nitrogen (BUN), morning urine microalbuminuria(MA) on empty stomach. All patients were done heart colour to exceed check, calculation left entricular mass index(LVIM), room wall middle shorten rate(mFS), blood early and late diastole filled with the speed ratio(E/A).Result:(1) Compared with the simple hypertension group, the microalbuminuria, endothelin-1in High blood pressure with left ventricular hypertrophy group (LVH) increase significantly(p<0.05), but the two groups in age, sex ratio, blood pressure (systolic blood pressure and diastolic blood pressure), creatinine, blood urea nitrogen index was not statistically significant(p>0.05). Logistic regression analysis shows that the high blood pressure happen left ventricular hypertrophy factors may have microalbuminuria, endothelin1, and body mass index(p<0.05).(2) Compared with the simple hypertension group, the microalbuminuria, endothelin-1in High blood pressure with left ventricular systolic function decline group increase significantly(p <0.05), but the two groups in age, sex ratio, blood pressure (systolic blood pressure and diastolic blood pressure), creatinine, blood urea nitrogen index was not statistically significant(p>0.05). Logistic regression analysis shows that the high blood pressure happen High blood pressure with left ventricular systolic function decline factors may have systolic blood pressure, microalbuminuria and endothelin-1(p<0.05).(3)Compared with the simple hypertension group, the endothelin-1in High blood pressure with left ventricular diastolic function to drop group increase significantly(p<0.05), but the two groups in microalbuminuria,age, sex ratio, blood pressure (systolic blood pressure and diastolic blood pressure), creatinine, blood urea nitrogen index was not statistically significant(p>0.05). Logistic regression analysis shows that the high blood pressure happen High blood pressure with left ventricular diastolic function decline factors may have age, systolic blood pressure, diastolic blood pressure and endothelin-1(p<0.05). Conclusion:1、Endothelial function of damage involved in the high blood pressure left ventricular damage occurred, the whole development process.2、High blood pressure is possible early many viscera and involvement, during which there may be some correlations. On the high blood pressure, we should assess many visceras of damage at the same time,and for early intervention.3、Regression analysis found that:left ventricular structure and function change, not only relevant with the blood pressure level about, still be age, endothelial function, body mass indexes, kidney and other factors.