Influence Of Removing Blood Stasis-turbid And Tonifying Liver And Kidney On Left Ventricular Hypertrophy And Left Ventricular Diastolic Function In Elderly Patients With Essential Hypertension

OBJECTIVE:It is to observe the influence of "NO.1 Granule "with functions of removing blood stasis-turbid and tonifying the liver and kidney on left ventricular hypertrophy and left ventricular diastolic function in the aged patient of hypertension grade II. And so as to give a new idea and method in evaluating the Curative effect of traditional Chinese medicine.MATERIALS AND METHODS:Totally 60 elderly patients with EH which treated in the Quanzhou Hospital of Tradional Chinese Medicine among August 2006 to February 2008 were adopted. The patients were randomly divided into two groups by numerical form. There were 30 in each group, which were the treatment group and the control group. Captopril was taken antihypertensive therapy to the control group, on the basis of using captopril the treatment group add "NO.1 Granule" treatment. The blood pressure and left ventricular mass index (LVMI) of the patients in each group were calculated and also the side effects were analyzed before entered the random experiment and after experiment. After one treatment course of 12 weeks, all the patients were evaluated in clinical effects and LVMI, and the efficacy of lowering pressure and symptom improvement . To analysis the changes of influence of left ventricular mass index, clinical effects and the side effects before and after treatment.RESULTS:(1) Two groups have the effect of lower the blood pressure after treatment. The scope of lower blood pressure of treatment group were greatest(P<0.05 or P<0.01).But there was a significant difference in DBP and SBP between two groups after treatment(P<0.05).(2) The blood pressure levels of the patients of the two groups were all cut down significantly, but the two groups exist an obvious difference compared with that in control group at the end of the fourth week(P<0.05),especially SBP lowered down more significantly (P<0.05).(3) The differences were extremely significant in the LVH of two groups before and after treatment(P<0.05 or P<0.01); The parameters of LVH such as LVDd,LVPW,IVS,and LVMI in treatment group were obviously lower than those in control group(P<0.05).(4) The ratio of E/A between the two groups was markedly increased before and after treatment(P<0.05).;(5) Heart rate between the two groups had no significant difference before and after treatment. (P>0.05);(6) Both of the groups had extremely significant differences in the physical symptoms, energy, and abilityof everyday life. In addition, Monomial symptoms score in treatment group were improved more obviously than that in control group(P<0.05 or P<0.01);(7) The differences of syndrome scores of two groups before and after treatment were extremely significant (P<0.01); There were significant differences between two groups after treatment in syndrome scores (P<0.05); the symptom curative effect between two groups had significant differences (P<0.01).CONCLUSIONS:(1) The "NO.1 Granule "could directly relsted to the improvement of clinical symptoms. In addition, there has an obvious advantage in monomial symptoms.(2) The comprehensive effects of "NO.1 Granule "combined with western medicine group were better that of group using the western medicine only.(3) The "NO.1 Granule" could significantly effectively lower down LVMI and could achieve the objective of lowering down the blood pressure and reversing the LVH.(4) The "NO.1 Granule"was no obvious toxicity, and it was safe for the clinical application.(5) It is a significant influence of "NO.1 Granule"with functions of removing blood stasis-turbid and tonifying the liver and kidney on left ventricular hypertrophy and left ventricular diastolic function in the aged patient of hypertension grade II. The "NO.1 Granule"could directly grasp the key pathogenesis of essential hypertension, embody the advantage in TCM treatment based on syndrome differentiation and integer concept, and it is to do basic clinical work well for the development of new Chinese drugs in essential hypertension.(6) the left ventricular hypertrophy and left ventricular diastolic function in the aged patient of hypertension were improved after 12 weeks clinical follow-up. But it is to need a long-term results of follow-up to ascertain the conclusion because EH is a common, lifelong disease, which serious damages people's health.