Tumor Markers VEGF And Liver Metastases Of Colorectal-Meta Analysis

Objective To explore the association of vascular endothelial growth factor (VEGF) expression and liver metastasis in human colorectal cancerMethods. We queried for VEGF expression in liver metastasis in human colorectal cancer profiling studies published between1990and2012. Excerpts from the literature in data (including basic characteristics, sensitivity and specificity) by the two independent completed.By the improved Newcastle-Ottawa Score methods we evaluate the quality of literature. Into standard:①The patients with and without a liver metastases controlled experiments.②The subjects of the pathology diagnosis of patients with colorectal cancer.③With the data extracted can we either directly or indirectly calculated OR value and95%confidence interval.④With immunohistochemical method and consistent positive standard tested the expression of VEGF. Exclusion standard:①Diagnosis cases is not clear;②No cases of liver metastases;③Data analysis methods are wrong, or does not provide;④Fails to provide directly or indirectly OR value;⑤Repeat literature. We analysis the datas by REVMAN4.2.2software.Conclusions According to the screening standards, there are15article1032cases of liver metastasis in colorectal cancer patients. In the literature, without liver metastases of the colorectal cancer the population is669people, the number is363people been spreading to the liver. The results show that liver metastasis were compared with patients without liver metastases of positive VEGF advantage than OR equal to0.17value,95%CI (0.12,0.23), Z value is equal to10.74, P<0.00001. Difference have statistical significance. The pre-treatment analysis showed that it is a total of553people without liver metastases and a total of300people with liver metastases of colorectal cancer.For the test for heterogeneity:P>0.05, we calculated the odds ratio in Fixed effects model.Analysis results:OR=0.21,95%CI (0.14,0.29),Z=8.72, P0.00001.Difference have statistical significance.After treatment, the results showed that the number of colorectal cancer without liver metastases is205people,and is72people with the liver metastases.For the test for heterogeneity:P>0.05,we calculated the odds ratio in Fixed effects model.Analysis results:R=0.07,95%CI (0.03,0.15), Z=6.55, P<0.00001.Difference have statistical significance.Conclusions:Vascular endothelial growth factor (VEGF) is closely related to colorectal cancer liver metastases can be an important reference index as a predictor of colorectal liver metastases.