The Role Of Cathepsin B And VEGF In The Aggressive Growth Of Meningioma

Objective： To examine the expression of Cathepsin B (Cat B) andvascular epidermal growth factor(VEGF) in meningiomas of humans and toinvestigate the relationship of Cat B and VEGF with the degree of malignancyand the role in the invasion process in meningiomas;To provide the basis fordiagnosis,treatment and prognosis of meningiomas.Method：we studied seventy-four cases diagnosed as meningiomas andten10cases of normal brain tissues during the same period in our hospital areused as the control group in the department of nuerosurgery of the FirstHospital of Jilin University by random during the Period from December,2009to June,2011. Immunohistochemical methods are used to determine the levelsof Cat B and VEGF. SPSS19.0is applied for the statistical analysis.The measurement data are compared by t-test, Spearman rank correlationanalysis is applied to analyze the relationship between Cat B and VEGFexpression in meningiomas.The difference is statistically significant (p﹤0.05).Results：Cat B is negative in10cases of normal brain tissue;Whencompared to the benign meningiomas,The expression of Cat B and VEGF inatypical meningioma and malignant meningioma, the difference is statisticallysignificant (p﹤0.05); There are significant differences between atypicalmeningioma and malignant meningioma in Cat B(p＜0.05) and VEGF(p﹤0.01); VEGF and Cat B expression are positively correlated(r=0.211, p﹤0.01).When compared to the control group,the difference is statistically significant inthe expression of Cat B and VEGF in meningioma (p﹤0.05);The expression ofCat B in invasive and noninvasive meningiomas of WHO grade I is: 6.80±1.99、5.33±3.66,when compared to the noninvasive meningiomasof WHO grade I,the invasive meningiomas is more positive, the difference isstatistically significant (p﹤0.05); The expression of VEGF in invasiveand noninvasive meningiomas of WHO grade I is:6.00±1.81、4.08±3.33,whencompared to the noninvasive meningiomas of WHO grade I,the invasivemeningiomas is more positive, the difference is statistically significant (p﹤0.05).There are18cases of meningeal skin cells, fibroblasts6cases,21cases of transitional type,6cases of hemangioma meningioma of51cases ofbenign meningiomas,the expression values of Cat B in these meningiomas are:6.06±3.52、5.17±2.29、5.57±3.64、6.17±4.19, there are no significantdifferences(P>0.05); the expression values of VEGF in these meningiomas are:4.67±3.62、4.67±2.02、4.52±2.88、5.00±5.81, there are no significantdifferences(p﹥0.05).There are1case is meningothelial meningioma and2cases is transitional meningioma of three cases of recurrent meningioma. Cat Band VEGF are highly expressed in the3cases of primary and recurrentmeningioma.Conclusion：1. The positive expressions of Cat B and VEGF in meningiomas aregradually increased with increasing levels of meningioma pathology;2. Cat B and VEGF expressions are positively correlated (r=0.211, p﹤0.01), and they may play a role in terms of the occurrence and invasive growthof the meningioma;3. The expressions of Cat B and VEGF in the invasive meningiomas aremore positive than the noninvasive meningiomas of WHO grade I; Cat B andVEGF can be used as one of the indicators in incursion and the prognosis of theWHO grade I meningioma.