The Correlational Study Between Serum Resistin And The Variability To Erythropoietin Responsiveness In Hemodialysis Patients

Objective: To measure serum concentrations of blood routine， renalfunction， blood lipids， serum albumin-reactive protein (CRP)， investigatingthe changes of serum resistin level with chronic renal failure patients and therelationship between serum resistin levels and other various influencingfactors， analyzing the correlation between serum resistin and erythropoietinresponsiveness.Method：Patients were divided into two groups: renal failure groupwithout dialysis(the points CKD3group，CKD4group，CKD5group)， thehemodialysis group (a group of hemodialysis1， a group of hemodialysis2)，separate the healthy control group. Selecting the random hemodialysis patientsfor a group of hemodialysis1， a group of hemodialysis2required: underwentHD for≥3months and intravenous EPO therapy to maintain a targethemoglobin (Hb) level of11.0g/dl. The ERI was defined as the weekly EPOdose per unit Hb per body weight. Using conventional methods detect Bloodcount， serum creatinine， serum albumin， serum total cholesterol，triglycerides. Serum resistin， EPO， IL-6were measured by sandwichenzyme-linked immunosorbent assay(ELISA).At the same time， we shouldnote sexuality， age， Height，weight dialysis duration.Result:1Serum resistin level of renal failure group without dialysis andthe hemodialysis group is significantly higher than the normal control group(P<0.01);Resistin level of hemodialysis group is higher than the renal failuredialysis group (P<0.01); hemodialysis is no significant difference betweengroup1and group2of hemodialysis patients (P>0.05). 2Serum resistin level of hemodialysis patients is positively correlatedwith their duration of dialysis， Scr and CRP (P <0.05)，negatively with eGFR.3Univariate analysis showed that ERI is significantly associated withBMI， CRP and resistin; multiple regression analysis showed that BMI，CRPresistin are significant determinants for EPO reactivity.4Basing on linear regression analysis (R~2=0.112，P=0.013)that confirmedthe association between ERI and resistin.Conclusion:1Serum resistin is closely related to inflammatory factors，considering that serum resistin may be an indicator that forecast inflammatoryresponsiveness of CKD.2serum resistin levels may be subject to the duration of dialysis andresidual renal function.3serum resistin levels may reflect on the responsiveness of erythropoietinin hemodialysis patients. Resistin in HD patients can be considered as a newmarker for EPO responsiveness.