Corticosteroids And Sodium Hyaluronate Alone, The Combination Of The Efficacy Of Knee Osteoarthritis

Background：Knee osteoarthritis (Kneeosteoarthritis, KOA) is the most commonclinical degenerative joint disease, the disease with recurrent joint pain,stiffness, joint swelling and joint movement disorder, characterized as the mainor joint deformity. KOA to occur in the elderly, women slightly outnumber men,the incidence of disease increased with age increase, is a serious health hazardin the elderly with chronic degenerative joint disease, is a common orthopedicsurgery and frequently-occurring disease. With our aging population andincreased life expectancy, the incidence of knee osteoarthritis rateincreases. Thus a simple, cheap and effective treatment is to explore the clinicalworkers have been objectives.Purpose：By observing the drug alone and combined intra-articular injectiontreatment of knee osteoarthritis clinical efficacy and clinical symptom scoresbefore and after treatment for drug combination therapy KOA provide atheoretical basis and clinical guidance.Method：To meet the clinical diagnosis of120cases of elderly arthritis of the kneewere randomly divided into three groups of40patients. The first group wastreated with intra-articular injection of sodium hyaluronate treatment, thesecond group were treated with intra-articular injection of corticosteroids, andthe third group were treated with intra-articular injection of sodium hyaluronateand corticosteroid combination therapy, treatment for5weeks.The use of the symptoms, signs quantitative scoring method5weeks after treatment, respectively, three groups of patients before and after the clinicalsymptom score, joint function to improve the situation and compares thesituation to maintain efficacy.Result：1、 three groups before treatment (Dl) classification of knee osteoarthritissymptoms and WOMAC Index of OA quantitative scoring more no statisticallysignificant difference; in pain and dysfunction score, the three groups ofpatients before treatment (D1) and treatment after (D35) compared three groupswere statistically significant (P <0.01). In the joint stiffness score, three groupsof patients before treatment (Dl) and after treatment (D35) compared threegroups were statistically significant (P <0.01)。2、 pain, joint stiffness and dysfunction score difference, in the first7days(Dl-7) between the two groups（Glucocorticoid and Sodium Hyaluronate）were significantly different (P <0.05). Sodium hyaluronate in the treatmentgroup and treatment group with glucocorticoid corticosteroids and sodiumhyaluronate in combination treatment group were significantly different (P<0.05). glucocorticoid in the treatment group with glucocorticoidcorticosteroids and sodium hyaluronate in combination treatment groupshowed no significant difference (P>0.05).3、in the35days，Sodium Hyaluronate in the treatment group withglucocorticoid corticosteroids and sodium hyaluronate in combinationtreatment group showed no significant difference (P>0.05)。glucocorticoid inthe treatment group with glucocorticoid corticosteroids and sodium hyaluronatein combination treatment group were significantly different (P <0.05)。Conclusion：1, the intra-articular injection of sodium hyaluronate, glucocorticoid andglucocorticoids and combination of sodium hyaluronate in the treatment KOA are effective, value for clinical use;2, glucocorticoids and the combination of sodium hyaluronate in treatmentof KOA than simply the use of sodium hyaluronate and intra-articular injectionof corticosteroids has a good, long-term efficacy。...