Effects Of External Applying Of Shuang Baisan Combined With Morphine In Relieving The Moderate And Severe Pain In The Patients With Primary Liver Cancer

ObjectiveThe objective of this study was to observe the clinical therapeutic efficacy and the quality of Life using shuang Baisan on relieving Pain and improving the quality of life of the primary liver cancer patients with the moderate and severe pain. to observe an effective, safe, economical and assistant medication in treating the cancer Pain.Methods34eligible Patients, having the moderate and severe pain of liver or upper abdominal, were divided into the treatment group (17patients) and and control group(17patients) in a double-blind, randomized, controlled,multi-center study. All patients were received7days treatment of ShuangBaisan(in treatment group)or placebo (in control group) by external application. Guided the patients to fill the NRS score and 《quality of life instruments QLQ-C30V3.0》, made an analysis of the score changes of NRS and quality of life after the treatment, then evaluated the effect of Shuang Baisan on relieving pain and improving the quality of life of the patients with primary liver cancerResultsAfter therapy, The NRS scores in the treated had showed a significant decreasing trend compared with those in control group in the corresponding (P<0.05), prompting the clinical effect in the treatment group were superior to that in the control group, and the best effect was the three hours after the start of the treatmen.Over time both of the downward trend was inconsistent which suggested that Shuang Baisan had a persistent effect in relieving pain. During the course of therapy, research group using average morphine was well bejow the corntoJ. Break pain of the both group patients had no significant diiference (P>0.05),which suggested that Shuang Baisa combined with morphine can reduce the amount of morphine.After therapy, the result in the quality of life showed that Patients in the treatment group had a better living quality in nausea and vomiting, constipation, diarrhea, appetite loss, languor etc than in the control group (P＜0.05), which suggested that Shuang Baisa can alleviate digestive tract reaction.in terms of KPS, Over time t he KPS in the treated had showed a signi ficant upwards trend compared with those in control group. The difference we staiistically significant(P<0.05).At the safety aspect, from data analysis of change for complete blood count and hepatic/renal function, None of these had adverse reactionsConclusionShuang Baisan had better effeet. on relieving pain combined with morphine in the primary liver cancer patients with the moderate and severe pain.lt could alleviate digestive tract reaction.of nausea and vomiting, constipation, diarrhea, appetile loss, languor etc due to reduce the dosage of morphine, it could improve the quality of life of the Patients, possessed the effect of improving the efficiency and depressing the toxicity. It had less side effeet and simple.These suggested shuang Baisan had better effeet on relieving pain combined with morphine. It would be an effective, safe and economical assistant medication for liver cancer pain.