Clinical Study On The Efficacy Of Shenqi Jiangtang Particles,in Treating Early Diabetes Nephropathy

BackgroundAccording to the United States, Japan and many Western European countries study, diabetic nephropathy (DN) has been promoted to the first cause of end-stage renal disease (ESRD). At present, the incidence trend of DN in China is rising, and it is one of the most leading causes of death in diabetic patients. Diabetic nephropathy (DN) is one of the most typical diabetic microangiopathy complications, also known as diabetic glomerulosclerosis. The clinical features of DN are albuminuria, progressive renal dysfunction, hypertension, edema, and severe renal failure in the late stages. It can be reversed the diabetic nephropathy In early stage under the right treatment. But once patients increased the urinary albumin excretion rate, the disease will be progressively, and following proteinuria, edema and so on, until the end stage renal failure in uremia. Therefore, the key to treat DN is early diagnosis and prevention diabetic nephropathy. Up till now, evidence-based medicine proves the effective treatment of diabetic nephropathy mainly through hypoglycemic, antihypertensive, regulating lipid, anticoagulation, limiting protein intake, and other Western symptomatic treatment. But there are still have some limitations. It is difficult to change the DN process fundamentally. So how to treat and prevent the DN effectively have become issues of common concern all over the world. Chinese medicine treatment of DN have effect on improving clinical symptoms, reduce the biochemical indicators, and to protect the kidneys. Therefore Chinese medicine prevention and treatment of diabetic nephropathy have huge potential and prospects. It is clinical and scientific important to do some research prevention or delay the occurrence of DN.ObjectiveClinical Observation on the Treatment of early diabetic nephropathy by Shenqi Jiangtang Particles, which is supplementd qi and nourishing yin nourished spleen and kidney.Methods63cases which meet the inclusion criteria were divided into three groups(control group, Observation groupn treatment group) by randomized, after3months of treatment. Testing the blood glucose, glycosylated hemoglobin, lipids, urinary albumin excretion rate, serum creatinine and effective of TCM syndromes etc. pre and post treatment. Evaluate its safety and efficacy, comprehensive evaluation the henqi Jiangtang Particles clinical effect in early diabetic nephropathy.ResultsStatistical analysis shows that it was no significant difference in comparable baseline data before treatment.Clinical studies have shown that the control group, treatment group, two groups of patients with clinical symptoms were improved to varying degrees, After treatment, blood glucose, glycosylated hemoglobin, lipids, and24-hour urine albumin quantitative than before treatment decreased, but the addition ofsugar granule of Chinese patent medicines Shenqi treatment group to improve the clinical symptoms and24-hour urinary albumin quantitative, blood glucose, glycosylated hemoglobin biochemical indicators better than the control group. There were no obvious adverse reactions during treatment.ConclusionAfter treatment, blood glucose, glycosylated hemoglobin, lipids,24-hour urine albumin quantitative were decreased in both groups. However, increasing the shenqi Jiangtang Particles in improving symptoms,24urinary albumin quantitative glucose, glucose metabolism showed better efficacy than western medicine only in the control group.