Expression And Clinical Signiifcance Of EIF4E CyclinD1and VEGF In Endometrial Proliferative Lesion And Endometrial Carcinoma

Objective: To study the expression of eukaryotic initiation factor4E (eIF4E)、CyclinD1、vascular endothelial growth factor （VEGF） and the correlation of themin endometrial hyperplasia and endometrial carcinoma. The study of the biologicalbehaviors of endometrioid adenocarcinoma are of important significance in theproper management of endometrioid adenocarcinoma.Methods: In30cases of normal proliferative endometrium,40cases of simplehyperplasia,15cases of complex hyperplasia，25cases of atypical hyperplasiaand65cases of endometrial carcinoma, the expressions of eIF4E、CyclinD1andVEGF were detected by means of immunohistochemical Elivision.Results:1.The positive expression of eIF4E in proliferative endometrium,simpleendometrial hyperplasia,complex endometrial hyperplasia,atypical hyperplasia andendometriod adenocarcinoma was13.33%,27.50%53.33%,64.00%and80.00%respectively, while CyclinD1was respectively6.67%,15.00%,26.67%,28.00%and75.38%, VEGF was10.00%,17.50%,33.33%,44.00%and76.92%respectively. TheeIF4E positive expression in complex endometrial hyperplasia,atypical hyperplasiaand endometriod adenocarcinoma was statistically significantly different from that innormal proliferative endometrium (P<0.05). The positive expression of eIF4E inendometriod adenocarcinoma was significantly different from complex endometrialhyperplasia (P<0.05).The eIF4E positive expression in atypical hyperplasia was notsignificantly different from that in complex endometrial hyperplasia(P>0.05). TheeIF4E positive expression in endometriod adenocarcinoma was related withpathological grade (P<0.05), not related with FIGO stage and lymph nodemetastasis(P>0.05).2.The expression of CyclinD1in endometrial carcinoma，complexhyperplasia and atypical hyperplasia was significantly higher than that in normal endometrium (P<0.05). The expression of CyclinD1in atypical hyperplasia andcomplex endometrial hyperplasia was not significantly different from that in simpleendometrial hyperplasia (P>0.05). The expression of CyclinD1in endometrialcarcinoma was significantly higher than that in atypical hyperplasia(P<0.05). TheCyclinD1positive expression in endometriod adenocarcinoma was related withpathological grade (P<0.05),not related with FIGO stage and lymph node metastasis(P>0.05).3.The expression of VEGF in endometrial carcinoma and atypicalhyperplasia was significantly higher than that in normal endometrium (P<0.05).The expression of VEGF in endometrial carcinoma was significantly different fromthat in atypical hyperplasia and complex endometrial hyperplasia (P<0.05). Theexpression of VEGF in endometrial carcinoma was significantly higher than that inatypical hyperplasia(P<0.05). The expression of VEGF in complex endometrialhyperplasia was not significantly different from that in atypical hyperplasia(P>0.05).The CyclinD1positive expression in endometriod adenocarcinoma was related withpathological grade (P<0.05),not related with FIGO stage and lymph node metastasis(P>0.05).4.Statistical analysis showed that there was positive significant correlationbetween eIF4E and CyclinD1expression in endometriod adenocarcinoma (r=0.246,P<0.05), positive significant correlation between eIF4E and VEGF(r=0.264,P<0.05),while CyclinD1and VEGF are the same (r=0.252, P<0.05)Conclusion:1The expression of eIF4E、CyclinD1and VEGF in endometriodadenocarcinoma was significantly higher than other groups, suggesting that they mayall be involved in the carcinomgesis of endometriod adenocarcinoma.2In the endometriod adenocarcinoma cases,the expression of eIF4E、 CyclinD1andVEGF was closely related to differentiation of tumors(P<0.05). They were not relatedto the FIGO stage and lymph node metastasis(P>0.05). eIF4E、 CyclinD1andVEGF may be of some usage in the differentiating diagnosis between pathologicalgrade.3Positive correlation could be found in the expression between eIF4E,CyclinD1and VEGF in endometriod adenocarcinoma.