Effect Of Prognosis For Plasma Concentration Of Amino-terminal Pro．Brain Natriuretic Peptide And D-dimer In Patients With Acute Cerebral Infarction

Background Cerebral infarction is a common disease. For the past fewyears, its incidence, mortality and morbidity obviously increased with thecontinuous improvement of living standards for people. Therefore,clinicians need to seek more effective indicators to determine the patient’scondition, prognosis and guide treatment. Recent studies suggest that brainnatriuretic peptide (Brain Natriuretic Peptide Revolution, BNP) andD-dimer are closely correlated to pathogenesy of cerebral infarction. Thereare significant change in BNP and D-dimer concentrations after acutecerebral infarction. Brain natriuretic peptide precursor N-terminal peptide(N-terminal proBNP, NT-proBNP) is the N-terminal fragment of the BNPhormone source disassociation. It has the advantage of high concentrations,long half-life, high sensitivity, easy detection. It may be more sensitivecompared with BNP[1]. Therefore, the purpose of our study was to explorethe relationship between acute cerebral infarction and NT-proBNP,D-dimer, which help to understand the extent of the damage, and prognosis of cerebral infarction, and to give more aggressive treatment. ObjectiveTo explore the relationship between N-terminal proBNP, NT-proBNP(NT-proBNP), D-Dimer and the prognosis in patients with acute cerebralinfarction. Methods A prospective control study was used. There were50patients in the acute cerebral infarction group, who were in hospitalwithin24h after onset, and20cases in the healthy control group. Theplasma level of NT-proBNP and D-Dimer on admission, general conditions,size of infarction, National Institute of Health stroke scale(NIHSS), andprognosis of follow-up for three month were observed. Results Theplasma levels of NT-proBNP and D-dimer were significantly higher in theacute cerebral infarction group than in control （P<0.05）;Its weresignificantly higher in patients with massive cerebral infarction ordisturbance of consciousness or hypertension than in patients withnon-massive cerebral infarction or without disturbance of consciousnessand hypertension（P<0.05）。After following-up for3months, death wasobserved in10patients.The plasma levels of NT-proBNP and D-dimerwere higher in the death group than the improved group. Conclusion Theplasma levels of NT-proBNP and D-dimer were increased after acutecerebral infarction. The greater was the infarct size, the higher were theplasma levels of NT-proBNP and D-dimer, the worse was the prognosis.Therefore, the plasma levels of NT-proBNP and D-dimer may become oneof the important and quick indexes to monitor the changes of condition and predict prognosis in patients with acute cerebral infarction.