Pre-operation Chemotherapy In Children Wilms’ Tumor:a Meta Analysis

Object： To evaluate the effect of clinical use of pre-operationchemotherapy in children wilms′tumor and provide references for furtherclinical treatment and scientific research.Method： According to the pre-developed search strategy, the followingdatabases are searched for the relevant articles: PUBMED, CochraneCentral Register of Controlled Trials(2011.3), OVID(include EMBASE andbiosis previews),VIP,CNKI,WANGFANG. Two independent people arearranged to pick up articles, collect data and check for each other. Thequalities of the articles are judged according to the criteria supporting bythe Cochrane handbook5.0.0. Stata11is used to do the statistic analysis.Result：30articles are included, which may be moderate or highpossibility of bias. We do Meta analyses for tumor shrinkage rate,tumorradical resection rate, event-free survival respectively： OR=37.28，95%CI(20.18，68.81)，P=0.0000；OR=5.923，95%CI(3.14，10.95)，P=0.000；OR=2.03，95%CI(1.58，2.60)，P=0.000Conclusion： Pre-operation chemotherapy could improve the tumorshrinkage rate and radical tumor resection rate,and it may improve the event-free survival rate in children wilms′tumor.