| Objective:To evaluate the changes of the tumor tissue and the feeding artery and neovascularization with pingyangmycin-lipiodol emulsion after the feeding artery TACE in the rabbit VX2tumor model.Methods:Twenty-eight rabbits bearing VX2liver tumor were randomly divided into four groups and each group contained7rabbits. The four group were ultrafluid lipiodol embolization group(group A), pingyangmycin group(group B), pingyangmycin-lipiodol emulsion group(group C),and control group(group D)。The size of tumors was observed by spiral CT scan, the volume(V1) were calculated,then The interventional therapy scheme performed as below:intraarterial ultrafluid lipiodol perfusion in group A;intraarterial pingyangmycin perfusion in group B;intraarterial pingyangmycin-lipiodol emulsion perfusion in group C; intraarterial saline solution perfusion in group D。All of subjects were sacrificed7days after TACE,the volume (V2) and growth rate of tumors were calculated, the liver was removed for histopathology examination。Results:The tumor volumes before therapy(V1) were (389.8±167.3),(404.1±184.9),(355.1±158.3),(378.1±189.0) mm3respectively, without differences found among them(F=0.257,P=0.856)。But the tumor volumes after TACE (V2) were (922.6±32.9),(665.9±99.9),(349.5±177.8)(1403.5±411.2)mm3respectively(F=26.23, P=0.0314). The tumor growth ratios were1.8,0.9,-0.04,2.5respectively. Mean positive ratio of VEGF were57.1%,42.9%,28.6%,100%respectively,showed a statistically significant difference each groups (F=8.407, P=0.044).The values of MVD was higher in group D (36.4±3.7)than other groups. The Values of MVD was significantly lower in group C(14.1±2.3) than other groups(p<0.05).statistical analysis showed a positive correlation between the expression of VEGF and MVD(r=0.743,P<0.01).Conclusion:The pingyangmycin has effective treatment outcomes in VX2rabbit liver tumor, and pingyangmycin-lipiodol emulsion in combination with transcatheter arterial chemoembolization is more effective. |
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