Clinical Security And Effect Of Dextromethorphan Chlorpheniramine Pseudoephedrine Solution In Post-cold Cough

ObjectionTo observe the clinical security and effect of dextromethorphan chlorpheniramine pseudoephedrine solution on post-cold cough.Materials and Methodsl.Case selection:from June2011to March2012, we selected128outpatients or inpatients with post-cold cough in the Department of Respiratory at Shandong Provincial Hospital. All of the patients meet the standard in 《Guideline on Diagnosis and Management of Cough(2009)》 made by Asthma disease group in Respiratory Disease Branch of China Medical Association.60cases were male, and the other68were female. They aged from20to60years with a median age of31.1years. Case selection criteria:Patients who had a history of the upper respiratory tract infection or acute bronchitis before, obtained basic control of the symptoms of respiratory tract infection and cold, had persistent cough maintained3to8weeks and less expectoration.(2) Patients whose hemogram, chest X-ray examinations were normal;(3) Patients who had normal pulmonary function tests, and patients who had shortness of breath or some other symptoms of airway hyperresponsiveness with negative bronchial provocation test;(4) Patients who didn’t have allergic diseases or atopic factors. Exclude self-infection aggravation, chronic pharyngitis, gastroesophageal reflux, upper airway cough syndrome and other causes of subacute cough;(5) Patients enrolled voluntarily after a detailed acknowledgement of the significance and notes of the study.2.Treatment methods:The voluntarily enrolled patients who were diagnosed as post-cold cough at the clinic or wards were randomly divided into two groups. One group was administered dextromethorphan chlorpheniramine pseudoephedrine solution three times a day,10ml per time. While the other group was administerd Compound Liquorice Tablets three times a day,3tablets per time as control. All patients were observed for10days, and stopped the medication on the11th day.3. Outcome measures:(1) cough symptom score and clinical efficacy evaluation;(2) comparison of the time (days) taken till the cough disappeared;(3) comparison of the incidence of the adverse reactions.4.Statistical methods:The data are the measurement data. Two groups of data expressed as mean±standard deviation (x±s), a significant test oft test was used, the approximation t’test was used when the heterogeneity of variance exists. Use SPSS13.0software to analysis data. Statistical differences were considered significant when P<0.05.Results:1.The cough symptom score and clinical efficacy evaluation comparison between the treatment group and the control group:After the treatment, the cough symptom score of the treatment group (1.78±1.25) is lower while compared with the control group (2.98±1.65), and the difference was significant (P<0.05). Clinical evaluation of the treatment group (total efficiency of87.9%) is higher than the control group (total efficiency of71.0%), and the difference was significant (P<0.05).2.Comparison of the time (days) taken till the cough disappeared:time taken for the treatment group [(4.3±2.7) days] is shorter than the control group (8.0±2.8) days], the difference was significant (P<0.05).3.Comparison of the incidence of adverse reactions:compared to the two sets of data the difference between the treatment group (10.61%) and the control group (9.68%) was not significant (P>0.05). ConclusionDextromethorphan chlorpheniramine pseudoephedrine solution in treating cough after a cold, can effectively alleviate the symptoms of cough, cough symptom scores decreased, and the low incidence of adverse reactions. This study shows that it has good safety and efficacy in the treatment of post-cold cough, and can be a choice of the treatment drugs of the post-cold cough.